Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients

Table 2 Multivariate Cox's regression hazard analyses

Survivin protein-level	Cytoplasm			Nucleus
	N	RR	P	N	RR	P
Svv weak (IRS = 3-4)	15	reference		10	reference
Svv negative(IRS = 0-2)	8	4.2	0.055	29	3.1	0.110
Svv moderate (IRS = 6-8)	19	5.7	0.004	11	5.7	0.022
Svv strong (IRS = 9-12)	8	2.4	0.241	none
Combined Svv protein levels
Svv cytopl. & nucleus weak (IRS = 3-4)¹	6	reference
Svv all other cases	35	9.4	0.024
Svv cytopl. & nucleus moderate+strong (IRS ≥ 6)²	9	24.8	0.003

Correlation of survivin expression in cytoplasm and/or nucleus with prognosis of leiomyosarcoma and synovial sarcoma patients.
Significant results are in bold face; ¹Survivin expression both in cytoplasm and in nucleus weak (all IRS = 3-4); ²Survivin expression in cytoplasm moderate or strong and survivin expression in nucleus moderate (all IRS ≥ 6)
Abbreviations: Svv-survivin; IRS-immunoreactive score; cytopl.-cytoplasma

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