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Table 3 Predictive accuracy of models built on Rotterdam participants when applied to Tarn participants.

From: A panel of kallikrein markers can predict outcome of prostate biopsy following clinical work-up: an independent validation study from the European Randomized Study of Prostate Cancer screening, France

  Clinical Model
  Any cancer High grade cancer
Base model 0.628 (0.552, 0.704) 0.767 (0.687, 0.847)
Full kallikrein panel 0.782 (0.719, 0.845) 0.870 (0.807, 0.933)
   without iPSA 0.753 (0.687, 0.818) 0.842 (0.776, 0.907)
   without fPSA 0.688 (0.619, 0.758) 0.795 (0.721, 0.868)
   without hK2 0.770 (0.706, 0.833) 0.853 (0.786, 0.919)
  1. Cancers with pathologic Gleason score 7 or higher were considered high grade. Base model includes age and total PSA (with splines) and DRE result. Full model includes age, total PSA (with splines), free PSA (with splines), intact PSA, hK2 and DRE result.