Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients

Mascolo, Massimo; Vecchione, Maria Luisa; Ilardi, Gennaro; Scalvenzi, Massimiliano; Molea, Guido; Di Benedetto, Maria; Nugnes, Loredana; Siano, Maria; De Rosa, Gaetano; Staibano, Stefania

doi:10.1186/1471-2407-10-63

BMC Cancer

Table 2 Clinical and pathological features and CAF-1/p60 immunohistochemical expression of 130 cases of CM ordered by Breslow depth

From: Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients

Case	Age (y)	Sex	Breslow	Ulceration	Mitosis	p60 r (%)	p60 r	p60 v (%)	p60 v	Follow-up (yrs)
1*	58	F	≤/= 1.00	no	< 1	10	+	17	+	12
2*	36	M	≤/= 1.00	no	≥ 1	11	+	15	+	12
3*	67	M	≤/= 1.00	no	< 1	10	+	18	+	12
4*	45	F	≤/= 1.00	no	≥ 1	10	+	13	+	12
5*	50	F	≤/= 1.00	no	< 1	12	+	15	+	11
6*	49	F	≤/= 1.00	no	≥ 1	14	+	18	+	11
7*	42	M	≤/= 1.00	no	< 1	10	+	14	+	10
8*	43	F	≤/= 1.00	no	≥ 1	12	+	14	+	9
9*	43	M	≤/= 1.00	no	< 1	13	+	16	+	9
10*	49	M	≤/= 1.00	no	≥ 1	28	++	37	+++	7
11*	40	M	≤/= 1.00	no	≥ 1	18	+	22	++	7
12*	41	M	≤/= 1.00	yes	< 1	15	+	25	++	7
13*	39	M	≤/= 1.00	no	< 1	27	++	45	+++	6 S (52 m**)
14*	37	F	≤/= 1.00	no	≥ 1	17	+	28	++	6
15	42	M	≤/= 1.00	no	< 1	12	+	16	+	14
16	37	M	≤/= 1.00	no	< 1	13	+	19	+	19
17	67	M	≤/= 1.00	no	≥ 1	11	+	14	+	14
18	66	M	≤/= 1.00	no	< 1	11	+	14	+	17
19	56	M	≤/= 1.00	no	≥ 1	10	+	23	++	2
20	35	M	≤/= 1.00	yes	≥ 1	15	+	20	++	7
21	32	F	≤/= 1.00	no	< 1	14	+	22	++	6
22	73	M	≤/= 1.00	no	≥ 1	10	+	14	+	21
23	74	F	≤/= 1.00	no	< 1	12	+	16	+	21
24	41	F	≤/= 1.00	no	≥ 1	10	+	14	+	14
25	48	F	≤/= 1.00	no	< 1	11	+	15	+	14
26	22	M	≤/= 1.00	no	≥ 1	12	+	15	+	14
27	24	F	≤/= 1.00	no	< 1	13	+	17	+	15
28	36	F	≤/= 1.00	no	≥ 1	28	++	50	+++	4 N (7 m)
29*	66	F	1.01 - 2.00	no	≥ 1	26	++	70	+++	12 N (8 m)
30*	65	F	1.01 - 2.00	no	< 1	20	++	24	++	12
31*	56	M	1.01 - 2.00	yes	≥ 1	21	++	26	++	12
32*	49	M	1.01 - 2.00	no	< 1	12	+	14	+	12
33*	48	M	1.01 - 2.00	no	≥ 1	11	+	15	+	12
34*	39	F	1.01 - 2.00	no	< 1	17	+	26	++	12
35*	47	F	1.01 - 2.00	yes	≥ 1	25	++	70	+++	12 N (7 m), M(60 m), D(144 m)
36*	51	M	1.01 - 2.00	no	< 1	10	+	22	++	11
37*	53	M	1.01 - 2.00	no	≥ 1	10	+	14	+	11
38*	56	M	1.01 - 2.00	no	< 1	11	+	14	+	11
39*	51	F	1.01 - 2.00	no	≥ 1	18	+	21	++	10
40*	45	F	1.01 - 2.00	no	< 1	10	+	15	+	10
41*	53	M	1.01 - 2.00	no	≥ 1	11	+	15	+	10
42*	67	M	1.01 - 2.00	no	< 1	12	+	14	+	10
43*	54	M	1.01 - 2.00	no	≥ 1	10	+	15	+	10
44*	34	M	1.01 - 2.00	no	≥ 1	13	+	22	++	9
45*	44	F	1.01 - 2.00	no	< 1	14	+	24	++	9
46*	43	F	1.01 - 2.00	no	< 1	11	+	23	++	9
47*	71	F	1.01 - 2.00	no	≥ 1	10	+	23	++	9
48*	34	M	1.01 - 2.00	no	< 1	15	+	20	++	9
49*	43	F	1.01 - 2.00	no	≥ 1	10	+	25	++	9
50*	51	F	1.01 - 2.00	no	< 1	12	+	14	+	9
51*	50	M	1.01 - 2.00	no	< 1	10	+	14	+	9
52*	39	F	1.01 - 2.00	no	< 1	25	++	40	+++	9 N (75 m)
53*	29	F	1.01 - 2.00	no	≥ 1	13	+	14	+	9
54*	42	M	1.01 - 2.00	no	< 1	11	+	14	+	7
55*	37	F	1.01 - 2.00	yes	≥ 1	27	++	50	+++	7 S (12 m), N(7 m)
56*	65	M	1.01 - 2.00	no	< 1	10	+	14	+	7
57*	43	M	1.01 - 2.00	no	≥ 1	23	++	45	+++	7 N(9 m)
58*	44	F	1.01 - 2.00	no	< 1	10	+	28	++	6
59*	18	F	1.01 - 2.00	no	≥ 1	15	+	27	++	4
60*	22	M	1.01 - 2.00	no	≥ 1	14	+	25	++	4
61*	24	M	1.01 - 2.00	no	< 1	12	+	22	++	4
62*	32	M	1.01 - 2.00	no	< 1	10	+	23	++	4
63*	30	F	1.01 - 2.00	no	< 1	12	+	21	++	4
64*	38	F	1.01 - 2.00	no	≥ 1	14	+	24	++	4
65*	37	M	1.01 - 2.00	no	< 1	15	+	23	++	3
66*	40	M	1.01 - 2.00	no	≥ 1	10	+	22	++	3
67	51	M	1.01 - 2.00	no	< 1	13	+	16	+	22
68	34	F	1.01 - 2.00	no	≥ 1	10	+	14	+	14
69	66	F	1.01 - 2.00	no	< 1	12	+	14	+	15
70	60	M	1.01 - 2.00	yes	< 1	11	+	14	+	13
71	48	F	1.01 - 2.00	no	≥ 1	10	+	14	+	14
72	28	M	1.01 - 2.00	yes	< 1	24	++	58	+++	2 N(3 m)
73	55	F	1.01 - 2.00	no	≥ 1	12	+	16	+	19
74	58	F	1.01 - 2.00	yes	≥ 1	28	++	50	+++	4 S
75	32	F	1.01 - 2.00	no	< 1	10	+	22	++	4
76	84	F	1.01 - 2.00	no	≥ 1	12	+	27	++	14
77	66	M	1.01 - 2.00	yes	≥ 1	26	++	47	+++	14 N(5,6 m), M(9,25,32 m)
78	75	F	1.01 - 2.00	yes	≥ 1	12	+	14	+	14
79	64	F	1.01 - 2.00	no	< 1	10	+	14	+	12
80*	40	M	2.01-4.00	no	< 1	11	+	14	+	12
81*	36	M	2.01-4.00	no	≥ 1	14	+	14	+	12
82*	39	M	2.01-4.00	no	< 1	10	+	22	++	11
83*	50	F	2.01-4.00	no	≥ 1	10	+	21	++	11
84*	48	F	2.01-4.00	no	< 1	14	+	25	++	11
85*	45	M	2.01-4.00	yes	≥ 1	27	++	57	+++	11 N(11 m), M(48 m), D(132 m)
86*	43	F	2.01-4.00	no	≥ 1	11	+	14	+	10
87*	53	F	2.01-4.00	no	< 1	15	+	25	++	10
88*	47	M	2.01-4.00	no	< 1	26	++	43	+++	10 N(3 m)
89*	54	M	2.01-4.00	no	≥ 1	12	+	24	++	10
90*	50	M	2.01-4.00	no	< 1	14	+	19	+	10
91*	69	F	2.01-4.00	no	≥ 1	12	+	14	+	10
92*	54	M	2.01-4.00	no	< 1	10	+	14	+	10
93*	53	M	2.01-4.00	no	< 1	10	+	22	++	9
94*	42	F	2.01-4.00	yes	≥ 1	25	++	68	+++	9 N(8 m), M(44 m), D(108 m)
95*	37	F	2.01-4.00	yes	≥ 1	26	++	60	+++	9 N(5 m), M(32 m)
96*	45	F	2.01-4.00	no	< 1	12	+	14	+	9
97*	49	F	2.01-4.00	yes	≥ 1	27	++	59	+++	9 N(12 m), M(22 m), D(108 m)
98*	32	M	2.01-4.00	yes	≥ 1	25	++	65	+++	7 N(10 m)
99*	38	F	2.01-4.00	yes	≥ 1	28	++	68	+++	6 N(10 m)
100*	38	M	2.01-4.00	no	< 1	12	+	25	++	3
101*	32	M	2.01-4.00	yes	≥ 1	29	++	60	+++	3 N(12 m), M(25 m)
102*	40	M	2.01-4.00	no	< 1	13	+	23	++	3
103*	46	F	2.01-4.00	no	≥ 1	24	++	65	+++	3 N(9 m)
104*	50	M	2.01-4.00	no	< 1	12	+	24	++	2
105*	17	M	2.01-4.00	no	< 1	22	++	55	+++	12 N(84 m)
106*	30	M	2.01-4.00	no	≥ 1	15	+	25	++	2
107*	32	F	2.01-4.00	no	< 1	20	++	36	+++	2
108	81	F	2.01-4.00	yes	≥ 1	22	++	50	+++	2 M(17 m)
109	56	F	2.01-4.00	no	< 1	12	+	27	++	13
110	22	F	2.01-4.00	yes	< 1	24	++	65	+++	2 N(3 m)
111	21	M	2.01-4.00	yes	< 1	14	+	22	++	14
112	60	F	2.01-4.00	no	≥ 1	25	++	60	+++	1 N(4 m)
113	33	F	2.01-4.00	yes	< 1	24	++	65	+++	1 M(8 m)
114	60	M	2.01-4.00	no	≥ 1	15	+	23	++	13
115	73	F	2.01-4.00	yes	< 1	22	++	70	+++	12 N(12 m)
116	42	M	2.01-4.00	yes	≥ 1	26	++	68	+++	6 N(6 m)
117	45	M	2.01-4.00	yes	< 1	25	++	63	+++	4 M(26,28 m)
118	56	F	2.01-4.00	no	≥ 1	24	++	70	+++	13 N(5 m)
119	53	F	2.01-4.00	yes	< 1	16	+	23	++	12
120	65	F	2.01-4.00	yes	≥ 1	26	++	65	+++	2 N(5 m)M(12 m)D(24 m)
121	38	F	>4.00	yes	< 1	24	++	60	+++	1 N(2 m)
122	55	F	>4.00	yes	< 1	17	+	21	++	14
123	56	F	>4.00	yes	< 1	23	++	68	+++	11 N(3 m), M(24 m)
124	69	M	>4.00	yes	≥ 1	18	+	22	++	6
125	81	F	>4.00	yes	< 1	24	++	58	+++	1 N(12 m)
126	52	F	>4.00	yes	< 1	28	++	70	+++	2 S(12 m), M(12 m), D(24 m)
127	30	F	>4.00	yes	≥ 1	29	++	63	+++	2 N(3 m), M(4 m), D(24 m)
128	54	M	>4.00	no	< 1	15	+	24	++	12
129	44	M	>4.00	yes	≥ 1	27	++	70	+++	12 N(3 m)
130	35	M	>4.00	yes	≥ 1	12	+	25	++	2

S: skin (dermal/hypodermal) metastasis; N: nodal metastasis; M: distant metastasis; D: death for disease; °P60r: CAF-1/P60 in radial growth phase; °°P60v: CAF-1/P60 in vertical growth phase; (*): cases previously matched for PARP-1 (poly-ADP-ribosyl)ase-1 expression; ** m = months.

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