Figure 3

CAF-1 expression in thick cutaneous melanoma. Thick cutaneous melanoma (Breslow thickness: > 4 mm) with diffuse over-expression of CAF-1/p60. This patient developed nodal and distant metastases and died for disease 2 years from diagnosis (3A: original magnification, ×150; 3B, ×200); Thick cutaneous melanoma, disease-free 12 years after surgery: moderate expression of CAF-1/p60 (3C: original magnification, ×150; 3D, ×200).