Figure 4From: Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands Coactivator overexpression increases proliferation and resistance to PPAR ligands in human breast cancer cell lines. (A) Triplicate cultures of stable CBP and SRC-1 expressing clones were grown in vitro for 6 days and compared to proliferation rates of neomycin resistant control cells (neo). Error bars indicate SEM of 3 independent experiments. (B, C) SRC-1, CBP, and neomycin resistant (neo) stable MCF7 or MDA-MB-468 clones were treated with 100 μM clofibrate (clo) or ciglitazone (cig) alone or in combination with 100 nM AGN194204 and grown in vitro for 6 days. Cells were counted with a hemacytometer. Error bars indicate SEM of 3 independent experiments.Back to article page