COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer

Table 3 Association of COX-2 expression with tumor characteristics by tumor receptor status¹

	All tumors		ER-negative		ER-positive		Her2 low		Her2 high		ER-negative/HER2 high
Spearman rank correlation	ρ	p-value	ρ	p	ρ	p	ρ	p	ρ	p	ρ	p
pAkt Ser473	0.23	<0.001	0.24	0.011	0.22	0.006	0.18	0.024	0.33	0.001	0.50	0.003
pAkt Thr308	0.26	<0.001	0.25	0.009	0.26	0.001	0.23	0.003	0.36	<0.001	0.51	0.003
pCasp9 Ser196	0.30	<0.001	0.31	0.001	0.30	<0.001	0.25	0.001	0.40	<0.001	0.67	<0.001
pBAD Ser136	0.20	0.001	0.26	0.008	0.15	0.063	0.13	0.084	0.31	0.002	0.57	<0.001
CD31	0.05	0.402	0.10	0.302	0.01	0.85	-0.02	0.799	0.19	0.084	0.41	0.021

¹ Spearman's correlation coefficient. Calculated with IHC scores 1-4 (negative, weak, moderate, strong) and continuous data (CD31)

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