Table 1 Clinical and pathological characteristics and univariate analysis for DFS

Sex

male

111 (73.5)

33.99

0.036*

female

40 (26.5)

21.13

Age

<55 years

74 (49.0)

21.45

0.330

≥55 years

77(51.0)

31.97

Smoking status

no

65 (43.0)

22.24

0.305

yes

86 (57.0)

32.99

Stage

I

54 (35.8)

NR^#

0.001*

II

47 (31.1)

33.64

III

50 (33.1)

15.18

T stage

T1

38 (25.2)

NR^#

0.03

T2

99 (65.5)

18.76

T3-4

14 (9.3)

38.16

N stage

N0

62 (41.1)

NR^#

<0.001*

N1

50 (33.1)

33.64

N2

39 (25.8)

13.37

Histology

Adenocarcinoma

59 (39.1)

17.41

0.004*

Non- adenocarcinoma

92 (60.9)

48.16

Surgery method

Wedge resection

5 (3.3)

17.41

0.958

Lobectomy

123 (81.5)

24.41

Pneumonectomy

23 (15.2)

31.15

Chemotherapy regimens

Docetaxel-containing

40 (26.5)

18.60

0.523

Vinorelbine- containing

40 (26.5)

48.16

Gemcitabine- containing

51 (33.8)

24.58

Paclitaxel- containing

20 (13.2)

24.41

TopIIα

Low expression

117 (77.5)

19.38

0.012*

High expression

34 (22.5)

NR

Ki67

Low expression

96 (63.6)

22.24

0.517

High expression

55 (36.4)

29.37