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Table 4 Impact of clinical and demographic characteristics on the risk of breast cancer in Brazilian women

From: Polymorphisms in regulatory regions of Cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study

Characteristic Category Cases Controls OR 95%CI P χ2
Age* (years) < 48 147 163 1   
  ≥ 48 171 110 1.72 (1.24-2.39) 0.001
Missing data   0 0    
Menarche (Age) < 12 120 93 1   
  ≥ 12 120 74 1.25 (0.84-1.86) 0.258
Missing data   78 106    
Menopause (Age)** ≤ 54 98 62 1   
  ≥ 55 10 5 0.79 (0.25-2.42) 0.68
Missing data   127 103    
First Birth (Age) ≤ 30 161 103 1   
  ≥ 31 or nulliparous 75 68 1.41 (0.93-2.13) 0.09
Missing data   82 102    
Fertile Time¥ < 35 45 35 1   
  ≥ 35 60 27 1.73 (0.83-3.42) 0.089
Missing data   3 5    
Use of contraceptives < 2 110 105 1   
  ≥2 92 59 1.49 (0.97-2.27) 0.065
Missing data   116 109    
Use of HRT θ no 79 43 1   
  yes 25 20 0.68 (0.32-1.44) 0.276
Missing data   4 4    
Use of NSAIDs no 187 154 1   
  yes 31 13 1.96 (0.99-3.88) 0.053
Missing data   100 106    
BMI Underweight: ≤ 18.4 9 1 4.13 (0.50-33.6) 0.28
  Normal: 18.5 - 24.9 98 45 1   
  Overweight: ≥ 25.0 159 63 1.15 (0.73-1.83) 0.55
Missing Data   52 164    
Smoking Habit no 174 83 1   
  yes 98 38 1.23 (0.77-1.94) 0.42
Missing data   46 152    
Color White 131 120    0.619‡
  Intermediate 125 96    
  Black 62 57    
Missing data   0 0    
  1. * 48 years old is the median of cases + controls; ** Menopausal status: postmenopausal: cases n = 108, controls: n = 67; premenopausal: cases: n = 83, controls n = 103; ¥ Age of Menopause - Age of Menarche (only for women in menopause); † For at least 2 years; θHRT: Hormonal Reposition Therapy (only for women in menopause); NSAIDs: Non-Steroidal Anti-Inflammatory Drugs; BMI: Body Mass Index at diagnosis (patients) or at recruitment (controls), BMI = weight (Kg)/height2 (m2); OR: Odds Ratio; 95%CI: 95% Confidence Interval; P from Chi-square test (Pearson p-value); ‡ P from Fisher test.