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Figure 5 | BMC Cancer

Figure 5

From: HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

Figure 5

Effects of HIF-1α-siRNA or CTM on Response to Radiation of U251MG and U343MG Cells (Radiosensitivity). A (U251MG) and B (U343MG), Clonogenic survival following treatment with the indicated siRNA (75 nM) and radiation under normoxia (0-10 Gy) and hypoxia (0-15 Gy). HIF-1α-siRNA decreased the hypoxia-induced radioresistance of U251MG and U343MG cells. Under normoxia, HIF-1α-siRNA reduces the response to irradiation in U251MG cells and enhanced the effect of radiation in U343MG cells. C (U251MG) and D (U343MG), Clonogenic survival following exposure to 75 nM CTM and radiation under normoxia (0-10 Gy) and hypoxia (0-15 Gy). Exposure to CTM decreased hypoxia-induced radioresistance of U251MG and U343MG cells. CTM enhanced the effect of radiation in U251MG cells and reduced the response to irradiation in U343MG cells under normoxia.

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