Figure 2

Clustering analysis over pathway modules. A) Heatmaps of pathway activation (blue = high relative activation, yellow = low relative activation) over the merged ER- and ER+ cohorts [2, 24, 40–44]. Color bars indicate the intrinsic subtype (Pink = HER2+, green = normal, dark-red = basal, skyblue = luminal A, blue = luminal B) and the cluster inferred using a variational Bayesian method [52]. B) Kaplan Meier plots for distant metastasis free survival (DMFS) for the predicted clusters in ER- and ER+ breast cancer, respectively.