Table 1 Microarray results with characteristics of 21 genes regulated by Taurolidine identified by Ingenuity pathway analysis
From: Gene expression analysis of cell death induction by Taurolidine in different malignant cell lines
Probe Set | Acession code | Gene symbol | Gene name | FC | Dir | Con | TRD | CD | CG | CC |
|---|---|---|---|---|---|---|---|---|---|---|
A_23_P214080 | NM_001964 | EGR1 | Homo sapiens early growth response 1 | 45,9 | ⇑ | 7,7 | 13,2 | 1 | 1 | 1 |
A_23_P34915 | NM_004024 | ATF3 | Homo sapiens activating transcription factor 3 | 39,9 | ⇑ | 8,8 | 14,1 | 0 | 1 | 1 |
A_23_P429998 | NM_006732 | FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 38,7 | ⇑ | 5,8 | 11,0 | 1 | 0 | 0 |
A_23_P106194 | NM_005252 | FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | 28,4 | ⇑ | 7,6 | 12,4 | 1 | 1 | 1 |
A_23_P131846 | NM_005985 | SNAI1 | snail homolog 1 | 27,6 | ⇑ | 7,4 | 12,2 | 1 | 0 | 0 |
A_24_P239606 | NM_015675 | GADD45B | growth arrest and DNA-damage-inducible, beta | 16,0 | ⇑ | 10,5 | 14,5 | 1 | 1 | 1 |
A_23_P207999 | NM_021127 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 = NOXA | 10,2 | ⇑ | 8,0 | 11,3 | 1 | 0 | 0 |
A_23_P23221 | NM_001924 | GADD45A | growth arrest and DNA-damage-inducible, alpha | 10,1 | ⇑ | 10,3 | 13,7 | 1 | 1 | 1 |
A_23_P131208 | NM_006186 | NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 9,2 | ⇑ | 5,3 | 9,0 | 1 | 0 | 1 |
A_23_P90172 | NM_014330 | PPP1R15A | protein phosphatase 1, regulatory (inhibitor) subunit 15A = GADD34 | 9,0 | ⇑ | 8,4 | 11,5 | 1 | 1 | 1 |
A_23_P436259 | NM_152461 | ERN1 | endoplasmic reticulum to nucleus signalling 1 = IRE1 | 8,3 | ⇑ | 6,9 | 10,0 | 1 | 0 | 0 |
A_23_P218463 | NM_013376 | SERTAD1 | SERTA domain containing 1 | 7,2 | ⇑ | 12,6 | 15,4 | 0 | 1 | 0 |
A_24_P921446 | BC017854 | EMP1 | epithelial membrane protein 1 | 6,7 | ⇑ | 5,9 | 8,6 | 1 | 0 | 0 |
A_23_P385034 | NM_001949 | E2F3 | E2F transcription factor 3 | 6,6 | ⇓ | 11,7 | 9,0 | 0 | 1 | 1 |
A_24_P278637 | NM_003824 | FADD | Fas associated death domain | 5,9 | ⇓ | 9,3 | 6,8 | 1 | 0 | 1 |
A_23_P362415 | BC001694 | UBE2B | ubiquitin-conjugating enzyme E2B | 5,7 | ⇑ | 4,5 | 7,0 | 1 | 0 | 1 |
A_24_P938293 | NM_005524 | HES1 | hairy and enhancer of split 1 | 5,4 | ⇑ | 9,7 | 12,1 | 0 | 1 | 1 |
A_23_P75921 | NM_145803 | TRAF6 | TNF receptor-associated factor 6 | 4,8 | ⇓ | 7,8 | 5,5 | 1 | 1 | 0 |
A_23_P408094 | NM_002357 | MXD1 | MAX dimerization protein 1 | 4,7 | ⇑ | 6,7 | 8,9 | 1 | 0 | 1 |
A_23_P254179 | NM_015339 | ADNP | activity-dependent neuroprotector | 4,3 | ⇓ | 10,8 | 8,7 | 1 | 1 | 0 |
A_24_P360674 | NM_078487 | CDKN2B | cyclin-dependent kinase inhibitor 2B | 4,1 | ⇑ | 4,8 | 6,6 | 0 | 1 | 1 |