Figure 9

Analysis of apoptosis in LLC tumors in syngeneic mouse lungs treated with either PBS (A) or rat UCMSCs (B) indicates that rat UCMSCs increase apoptotic cell death. Lungs were collected, and apoptosis in tumors was analyzed by evaluating the area of TUNEL positive cells (panels A and B) as described in Materials and Methods. The average TUNEL positive area(C) were determined by analyzing ten tumor areas in each treatment group and expressed as fold change compared to PBS-treated controls.