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Table 4 Results of other studies investigating an escalation of the dose of WBI beyond 30 Gy in patients with brain metastases from a relatively radioresistant tumor.

From: Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis

Reference

Design

N patients

Tumor type

Median survival

Cannady et al. [8]

retrospective

46

renal cell carcinoma

30 Gy: 2.7 mos. >30 Gy: 8.5 mos.

Isokangas et al. [18]

retrospective

60

malignant melanoma

30 Gy: 4.1 mos. >30 Gy: 9.6 mos.

Present study

retrospective

164

various

30 Gy: 3.3 mos. >30 Gy: 9.5 mos