Table 3 Stratified analysis of the CYP2E1 DraI polymorphism and HNSCC
Sub-grouped studies | Genetic model | No.of Studies | No.Cases/No.Controls | Test of association | Test of heterogeneity | |||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | OR (95% CI) | P | Q | P Q | I 2 |
Overall | AT vs. TT | 9 | 2407/2126 | 1.15(0.90-1.47) | 0.25 | 19.92 | 0.011 | 59.84 |
| Â | AA vs. TT | 9 | 2407/2126 | 1.56(1.06-2.27) | 0.021 | 8.62 | 0.37 | 7.21 |
| Â | Dominant | 9 | 2407/2126 | 1.18(0.94-1.49) | 0.13 | 18.81 | 0.016 | 57.47 |
Asians | AT vs. TT | 2 | 486/561 | 0.92(0.70-1.19) | 0.53 | 0.13 | 0.71 | 0 |
| Â | AA vs. TT | 2 | 486/561 | 1.99(1.22-3.24) | 0.006 | 0.067 | 0.79 | 0 |
| Â | Dominant | 2 | 486/561 | 1.04(0.81-1.34) | 0.72 | 0.37 | 0.53 | 0 |
Caucasians | AT vs. TT | 7 | 1921/1601 | 1.24(0.92-1.66) | 0.15 | 14.61 | 0.02 | 58.95 |
| Â | AA vs. TT | 7 | 1921/1601 | 1.08(0.59-1.97) | 0.78 | 6.18 | 0.40 | 2.98 |
| Â | Dominant | 7 | 1921/1601 | 1.22(0.90-1.65) | 0.18 | 16.29 | 0.01 | 63.17 |
High quality | AT vs. TT | 7 | 2189/1663 | 1.12(0.83-1.51) | 0.43 | 18.33 | 0.005 | 67.27 |
| Â | AA vs. TT | 7 | 2189/1663 | 1.28(0.81-2.03) | 0.28 | 5.89 | 0.43 | 0 |
| Â | Dominant | 7 | 2189/1663 | 1.13(0.85-1.49) | 0.38 | 17.11 | 0.009 | 64.93 |
Low quality | AT vs. TT | 2 | 218/499 | 1.19(0.82-1.72) | 0.35 | 1.59 | 0.20 | 37.10 |
| Â | AA vs. TT | 2 | 218/499 | 2.36(1.20-4.63) | 0.012 | 0.56 | 0.45 | 0 |
| Â | Dominant | 2 | 218/499 | 1.35(0.95-1.92) | 0.085 | 1.25 | 0.26 | 20.00 |