Figure 3

Body weights, tumor volumes and multiplicity of metastasis in mammary carcinomas. Raloxifene was administered with mini-osmotic pumps. Each group consisted of 10 mice. A. Body weights of mice treated with 18 and 27 mg/kg/day raloxifene were significantly decreased throughout the experiment as compared with the control group, but only by 10% (*P < 0.05; **P < 0.01). B. Tumor volumes in the 18 and 27 mg/kg/day groups began to decrease significantly as compared to the control values starting at week 3, and the differences became even more pronounced by the termination of the experiment (week 6) (*P < 0.05; **P < 0.01). C. Multiplicity of lymph node metastasis was significantly decreased in the 27 mg/kg raloxifene group (*P < 0.05). D. Multiplicity of lung metastasis tended to be reduced in the 27 mg/kg raloxifene group. Data are presented as means ± SD.