The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

BMC Cancer

Table 2 Association of rs7566605 with BMI and BC risk.

rs7566605	CC	GC	GG	P-values
Cases	562	572	135
Controls	944	1,008	242
OR ^a (BC risk)	1	0.95 (0.82-1.10)	0.93 (0.74-1.19)	0.466^c
Normal weight (BMI <25)	797	862	208
Overweight (BMI <30)	656	624	143
Obese (BMI ≥30)	295	308	80
BMI^b	26.08 (25.87-26.30)	26.00 (25.78-26.21)	26.05 (25.62-26.48)	0.697^c
OR overweight or obese^d	1	0.90 (0.79-1.03)	0.88 (0.71-1.08)	0.104^c
OR obese^d	1	0.95 (0.79-1.15)	1.00 (0.75-1.34)	0.823^c

^aOR: odds ratio for BC risk from conditional logistic regression analysis on matched data; cases of carcinoma in situ and their controls were excluded from the analysis, the C allele was taken as reference.
^bBody Mass Index. Adjusted for age and case-control status; cases of carcinoma in situ and their controls were included in the analysis, mean (5th - 95th percentiles)
^cP test of trend
^dOR: odds ratio from unconditional logistic regression comparing this outcome to normal weight, adjusted for age and case-control-status. The C allele was taken as reference.

ISSN: 1471-2407