Table 1 Clinical and anatomo-pathological characteristics of rectal tumors analyzed for 33 microsatellites
With preoperative treatment (33 MS allelotyping) n = 24 | |||||
|---|---|---|---|---|---|
Total tumors n = 119 | Without preoperative treatment (33 MS allelotyping) n = 33 | With preoperative radiotherapy n = 16 | With preoperative radio-chemotherapy n = 8 | ||
Age | Median | 66.5 years | 69 years | 68 years | 61 years |
Range | [24; 89] | [34; 87] | [44; 82] | [42; 68] | |
Sex Ratio | Male | 83 | 22 (66.7%) | 11 (68%) | 7 (87.5%) |
Female | 36 | 11 (33.3%) | 5 (32%) | 1 (12.5%) | |
UICC Staging | 0-I | 34 | 12 | 3 | |
II | 33 | 6 | 6 | ||
III | 25 | 8 | 4 | ||
IV | 27 | 7 | 11 | ||
Localization | [0; 5 cm] | 53 | 9 | 11 | 3 |
]5; 10 cm] | 44 | 13 | 5 | 5 | |
]10; 15 cm] | 22 | 11 | 0 | 0 | |
Stromal Inflammation* | No inflammation | 81 (68.1%) | 26 (78.8%) | 14 (58.3%) | |
Inflammation | 38 (31.9%) | 7 (21.2%) | 10 (41.6%) | ||
Differenciation* | Not differentiated | 4 (3.3%) | 0 (0%) | 2 (8.3%) | |
Middle differentiated | 39 (32.8%) | 13 (39.4%) | 7 (29.3%) | ||
Well differentiated | 76 (63.9%) | 20 (60.6%) | 15 (62.5%) | ||
Angio-invasion* | No angio-invasion | 101 (84.9%) | 26 (78.8%) | 6 (25%) | |
Angio-invasion | 18 (15.1%) | 7 (21.2%) | 18 (75%) | ||
Local recurrence rate at 2 years | 8.3% | 6.1% | 8.3% | ||
Metastatic relapse at 2 years | 22.7% | 18.1% | 29.2% | ||
2 years overall survival | 91% | 89% | 81% | ||