Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11

BMC Cancer

Table 1 Samples

Case	Breed	Age	Sex	Tumor Site	c-KIT Mutations	PDGFRA Mutations
1	Cockapoo	13	FS	stomach	exon 11 deletion, exon 11 SNP	normal
2	German Wirehaired Pointer	10.5	FS	cecum	exon 11 deletion	exon 12 SNP, exon 14 SNP
3	Cocker Spaniel	12	FS	small intestine	normal	normal
4	Labrador Retriever	4	FS	duodenum	normal	normal
5	American Pit Bull Terrier	15	FS	cecum	exon 11 deletion	normal
6	Golden Retriever	13	F	small intestine	normal	normal
7	Collie	12	M	jejunum	exon 11 SNP	normal
8	Boxer	10	M	jejunum	normal	normal
9	Cocker Spaniel	US	FS	small intestine	exon 11 SNP	normal
10	Irish Setter	11	FS	small intestine	normal	normal
11	Golden Retriever	10.5	MN	cecum	exon 11 SNP	normal
12	Springer Spaniel	10.6	FS	cecum	exon 11 deletion	normal
13	Labrador Retriever	8.5	FS	jejunum	normal	normal
14	German Shorthaired Pointer	9	FS	small intestine	normal	exon 12 SNP
15	Labrador Retriever cross	10	MN	ileocecocolic junction	exon 11 deletion	normal
16	Mixed	9	FS	cecum	exon 11 deletion	exon 12 SNP, exon 14 SNP
17	Mixed	15	MN	jejunum	normal	normal

Signalment and site of canine gastrointestinal stromal tumor cases analyzed in this study. FS = female spayed, MN = male neutered, US = unspecified.

ISSN: 1471-2407