Figure 6
Reduction of integrin expression and MMP activity by rhFNHN29 and rhFNHC36. (A-1), Representative immunoblots for integrin αv, β3 and β1 proteins. (A-2), The group data represents the mean ± SD (n = 3). The densitometry data were normalized to β-actin. * denotes a statistically significant difference compared to the control (P < 0.05) and # denotes a statistically significant difference compared to rhFNHN29 at the same concentration (P < 0.05) by One-Way ANOVA. (B-1), Analysis of MMP activity. Supernatants from MHCC97H cells cultured with Mn2+ in the absence or presence of different concentrations of rhFNHN29 and rhFNHC36 were performed by Gelatin Zymography. (B-2), The group data of enzymolysis strip volume represent mean ± SD (n = 3). * denotes a statistically significant difference compared to the control (P < 0.05) and # denotes a statistically significant difference compared to rhFNHN29 at the same concentration (P < 0.05) by One-Way ANOVA.