Figure 4
From: PDGF-B-driven gliomagenesis can occur in the absence of the proteoglycan NG2
PDGF-B-induced tumors recruit OPCs also in the absence of NG2 expression. (A-H) Immunofluorescence stainings of NG2-KO (A-D) and wild type (E-H) glioma sections with anti-GFP antibody in green, DAPI for nuclear staining in blue and antibodies for the indicated antigens in red. The left column of the figure corresponds to tumor infiltrated regions, while pictures on the right represent normal brain regions next to tumor areas showing the basal level of OPC markers expression for comparison. Scale bars: 50 μm