Figure 1
From: PDGF-B-driven gliomagenesis can occur in the absence of the proteoglycan NG2
PDGF-B transduction induces an oligodendroglial fate in cultured neural progenitor cells. (A-B, left side) Histograms showing the percentage of Olig2-positive cells in PDGF-B (red bars) and control (green bars) transduced cortical (A) and GE (B) cultures obtained from wild type and NG2-KO embryos. (A-B, right side) Immunofluorescence micrographs of cortical (A) and GE (B) cultures derived from wild type and NG2-KO mice following the transduction with PDGF-B/GFP or control retroviruses. The immunoreactivity to Olig2 and GFP is shown in red and in green, respectively. NG2-KO cultures: nExp = 3; Wild type cultures: nExp = 2. *p < 0.05 and **p < 0.01 in a 2-tailed Student's t-test. Scale bar: 50 μm