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Table 7 Correlation between consensus immunohistochemistry and FISH results for core needle biopsy and surgically resected specimens.

From: HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

Core needle biopsy specimens
  Number of tumors (%)
  Total HER2 gene amplification by FISH
   Positive Equivocal* Negative
HER2 IHC score
3+ 21 20 (95) 0 (0) 1 (5)
2+ 19 11 (58) 0 (0) 8 (42)
0 or 1+ 60 2 (3) 0 (0) 58 (97)
Total 100 33 (33) 0 (0) 67 (67)
Surgically resected specimens
  Number of tumors (%)
  Total HER2 gene amplification by FISH
   Positive Equivocal* Negative
HER2 IHC score
3+ 10 10(100) 0 (0) 0 (0)
2+ 7 3 (43) 0 (0) 4 (57)
0 or 1+ 8 0 (0) 0 (0) 8 (100)
Total 25 13 (52) 0 (0) 12 (48)
  1. *For three tumors, FISH judgment was equivocal by the first counts, but by the second counts, the judgments changed into positive (Table 3). FISH, fluorescence in situ hybridization