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Table 1 Core needle biopsy tumor specimens for which interobserver disagreement arose regarding the results of HER2 immunohistochemistry

From: HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

Code Final score IHC score FISH (HER2/CEP17)
   Observer A Observer B Observer C  
B45 1+ 1+ 1+ 2+ - (0.96)
B78 1+ 1+ 1+ 2+ - (0.99)
B24 1+ 2+ 1+ 1+ - (1.01)
B82 1+ 2+ 1+ 1+ - (1.02)
B79 1+ 2+ 1+ 1+ - (1.05)
B99 1+ 1+ 1+ 2+ - (1.07)
B36 1+ 1+ 1+ 2+ - (1.11)
B22 2+ 2+ 1+ 2+ - (0.97)
B69 2+ 2+ 1+ 2+ - (1.04)
B43 2+ 2+ 1+ 2+ - (1.09)
B86 2+ 2+ 1+ 2+ - (1.39)
B29 2+ 2+ 2+ 1+ - (1.42)
B100 2+ 2+ 1+ 2+ + (2.38)
B16 2+ 3+ 2+ 2+ + (2.56)
B97 2+ 2+ 1+ 2+ + (4.56)
B52 2+ 3+ 2+ 2+ + (5.44)
B91 2+ 2+ 2+ 3+ + (6.80)
B90 2+ 3+ 2+ 2+ + (10.38)
B102 2+ 3+ 2+ 2+ + (12.62)
B50 3+ 3+ 3+ 2+ + (5.11)
B7 3+ 3+ 2+ 3+ + (8.83)
B96 3+ 3+ 2+ 3+ + (9.02)
B95 3+ 3+ 2+ 3+ + (10.92)
B27 3+ 3+ 3+ 2+ + (12.50)
  1. The HER2 score was assigned according to the 2007 ASCO/CAP guideline [10]. The majority score was assigned as the final score for the tumor.
  2. FISH, fluorescence in situ hybridization; IHC, immunohistochemistry