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Table 1 Core needle biopsy tumor specimens for which interobserver disagreement arose regarding the results of HER2 immunohistochemistry

From: HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

Code

Final score

IHC score

FISH (HER2/CEP17)

  

Observer A

Observer B

Observer C

 

B45

1+

1+

1+

2+

- (0.96)

B78

1+

1+

1+

2+

- (0.99)

B24

1+

2+

1+

1+

- (1.01)

B82

1+

2+

1+

1+

- (1.02)

B79

1+

2+

1+

1+

- (1.05)

B99

1+

1+

1+

2+

- (1.07)

B36

1+

1+

1+

2+

- (1.11)

B22

2+

2+

1+

2+

- (0.97)

B69

2+

2+

1+

2+

- (1.04)

B43

2+

2+

1+

2+

- (1.09)

B86

2+

2+

1+

2+

- (1.39)

B29

2+

2+

2+

1+

- (1.42)

B100

2+

2+

1+

2+

+ (2.38)

B16

2+

3+

2+

2+

+ (2.56)

B97

2+

2+

1+

2+

+ (4.56)

B52

2+

3+

2+

2+

+ (5.44)

B91

2+

2+

2+

3+

+ (6.80)

B90

2+

3+

2+

2+

+ (10.38)

B102

2+

3+

2+

2+

+ (12.62)

B50

3+

3+

3+

2+

+ (5.11)

B7

3+

3+

2+

3+

+ (8.83)

B96

3+

3+

2+

3+

+ (9.02)

B95

3+

3+

2+

3+

+ (10.92)

B27

3+

3+

3+

2+

+ (12.50)

  1. The HER2 score was assigned according to the 2007 ASCO/CAP guideline [10]. The majority score was assigned as the final score for the tumor.
  2. FISH, fluorescence in situ hybridization; IHC, immunohistochemistry