Table 4 Mean serum total homocysteine levels according to Dukes' stage and SHMT1 1420/ MTHFR 677 diplotypes in colon and rectal cancer patients and respective controls
From: SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer
Mean serum total homocysteine* (95% CI) [μM] | ||||
|---|---|---|---|---|
Dukes' stage | Control | Colon cancer | Control | Rectal cancer |
17.9 (17.3-18.5) | 17.7 (17.1-18.3) | |||
A, B | 19.4 (16.9-21.8) | 18.3 (16.9-19.6) | ||
C | 20.8 (19.1-22.5)° | 19.1 (17.9-20.2)° | ||
D | 21.6 (20.7-22.6)° | 20.4 (19.6-21.3)° | ||
p† = 0.031 | p† = 0.036 | |||
for trend p = 0.059 | for trend p = 0.053 | |||
SHMT1/MTHFR | Control | Colon cancer** | Control | Rectal cancer** |
CC/CC | 15.6 (14.2-17.0) | 20.7 (18.9-22.5)° | 15.9 (14.6-17.2) | 19.4 (18.0-20.8)° |
CC/CT+TT | 16.2 (15.1-17.4) | 21.5 (20.1-22.8)° | 15.3 (14.4-16.1) | 21.0 (19.7-22.2)° |
CT+TT/CC | 19.1 (17.9-20.2)# | 22.8 (21.0-24.5)° | 19.3 (18.1-20.5)# | 19.6 (17.9-21.4) |
CT+TT/CT+TT | 20.3 (19.1-21.6)# | 21.4 (19.8-23.0) | 19.8 (18.6-21.0)# | 20.8 (19.7-21.9) |
p† < 0.0001 | p† = 0.155 | p† < 0.0001 | p† = 0.221 | |