Table 3 Colon and rectal cancer risk based on SHMT1 1420/MTHFR 677 diplotypes
From: SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer
Diplotypes | Colon cancer | Rectal cancer | ||
|---|---|---|---|---|
SHMT1/MTHFR | case/control | OR* (95% CI) | case/control | OR* (95% CI) |
CC/CC | 93/89 | 1.00 (reference) | 103/91 | 1.00 (reference) |
CC/CT+TT | 132/131 | 0.95 (0.65-1.39) | 146/129 | 0.99 (0.69-1.44) |
CT+TT/CC | 115/127 | 0.87 (0.59-1.27) | 87/135 | 0.57 (0.39-0.84)† |
CT+TT/CT+TT | 132/114 | 1.10 (0.75-1.62) | 143/123 | 1.02 (0.71-1.48) |