Table 1 Selected characteristics and genotype frequencies of SHMT1 C1420T and MTHFR C677T polymorphisms of patients with colon cancer, rectal cancer and that of the respective controls
From: SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer
Parameters | Control | Colon cancer | p | Control | Rectal cancer | p |
|---|---|---|---|---|---|---|
n = 461 | n = 476 | n = 478 | n = 479 | |||
n (%) | n (%) | n (%) | n (%) | |||
Age (years) | ||||||
mean ± SD | 59.2 ± 12.4 | 59.5 ± 11.9 | 0.733 | 58.9 ± 11.1 | 58.9 ± 10.5 | 0.938 |
< 60 | 230 (50) | 226 (47) | 0.300 | 246 (51) | 238 (50) | 0.437 |
≥60 | 231 (50) | 250 (53) | 232 (49) | 241 (50) | ||
Sex | ||||||
male | 218 (47) | 227 (48) | 0.863 | 304 (64) | 302 (63) | 0.803 |
female | 243 (53) | 249 (52) | 174 (36) | 177 (37) | ||
BMI | ||||||
mean ± SD | 26.2 ± 3.9 | 26.2 ± 4.0 | 1.000 | 26.5 ± 3.5 | 26.4 ± 4.3 | 0.882 |
Dukes' stage | ||||||
A | 3 (1) | 3 (1) | ||||
B | 107 (22) | 102 (21) | ||||
C | 181 (38) | 220 (46) | ||||
D | 185 (39) | 154 (32) | ||||
SHMT1 C1420T | ||||||
CC | 220 (48) | 228 (48) | 0.360 | 220 (46) | 249 (52) | 0.002 |
CT | 186 (40) | 201 (42) | 198 (41) | 192 (40) | ||
TT | 55 (12) | 47 (10) | 60 (13) | 38 (8) | ||
CT+TT | 241 (52) | 248 (52) | 0.939 | 258 (54) | 230 (48) | 0.009 |
MTHFR C677T* | ||||||
CC | 216 (47) | 208 (44) | 0.396 | 226 (47) | 190 (40) | 0.002 |
CT | 186 (40) | 196 (42) | 194 (41) | 231 (48) | ||
TT | 59 (13) | 68 (14) | 58 (12) | 58 (12) | ||
CT+TT | 245 (53) | 264 (56) | 0.230 | 252 (53) | 289 (60) | 0.001 |
SHMT1 /MTHFR | ||||||
CC/CC | 89 (19) | 93 (20) | 0.160 | 91 (19) | 103 (22) | < 0.001 |
CC/CT+TT | 131 (29) | 132 (28) | 129 (27) | 146 (30) | ||
CT+TT/CC | 127 (28) | 115 (24) | 135 (28) | 87 (18) | ||
CT+TT/CT+TT | 114 (24) | 132 (28) | 123 (26) | 143 (30) | ||
Serum total homocysteine | ||||||
mean ± SD | 17.9 ± 6.9 | 20.8 ± 6.5 | < 0.0001 | 17.7 ± 6.6 | 19.1 ± 5.9 | < 0.0001 |