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Table 6 Univariate factors associated with 90-day mortality in patients with AML.

From: Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study

Characteristic 90-Day Status p-value
  Dead
(n = 25)
Alive
(n = 20)
 
Age (mean [SD]) 59.4 (11.7) 49.8 (12.9) 0.01
≥ 2 co-morbidities (%) 12 (52.2) 9 (40.9) 0.55
AML M1 Subtype (%) 12 (48.0) 3 (15.0) 0.03
Poor cytogenetic profile (%) 6 (26.1) 7 (31.8) 0.75
Time from AML diagnosis to ICU (d) 65 (12-288) 40 (9-95) 0.61
Relapse/refractory AML status (%) 8 (32.0) 5 (25.0) 0.75
Duration of neutropenia (d) (med [IQR]) 15 (13-19) 15 (13-19) 0.80
Chemotherapy in ICU (%) 1 (4.0) 6 (30.0) 0.03
Sepsis diagnosis (%) 8 (32.0) 6 (33.3) 1.0
APACHE II score (mean [SD]) 32.4 (10.7) 28.0 (9.5) 0.15
SOFA score (mean [SD]) 14.6 (4.3) 11.4 (3.3) 0.007
Delta SOFA (day 1) (med [IQR]) 1 (0 to 3) 0 (-2 to 2) 0.02
Delta SOFA (day 3) (med [IQR]) 2 (-1 to 4) -2 (-4 to 2) 0.02
SOFA (maximum) (mean [SD]) 12.1 (5.3) 10.8 (3.1) 0.46
MAP <60 mmHg (%) 11 (44.0) 4 (22.2) 0.20
Lactate (mmol/L) (mean [SD]) 4.1 (4.6) 2.1 (1.7) 0.08
Vasoactive therapy (%) 22 (88.0) 12 (60.0) 0.04
Shock (%) 25 (100) 13 (72.2) 0.009
Platelets (10 9 cells/L) (med [IQR]) 17 (9-37) 14 (10-31) 0.90
Bilirubin (μmol/L) (mean [SD]) 40.5 (37.3) 31.1 (15.7) 0.30
P/F ratio (mean [SD]) 116 (88) 149 (100) < 0.001
Mechanical ventilation (%) 21 (84.0) 9 (45.0) 0.01
Creatinine (μmol/L) (mean [SD]) 148 (59) 176 (108) 0.28
Renal replacement therapy (%) 7 (28.0) 5 (25.0) 1.0
G-CSF (%) 17 (68.0) 9 (47.4) 0.22
Corticosteroids (%) 13 (52.0) 9 (47.4) 1.0
Withdrawal of support (%) 16 (64.0) 0 (0) < 0.001
  1. Abbreviations: d = days; SOFA = sequential organ failure assessment; APACHE = acute physiology and chronic health evaluation; MAP = mean arterial pressure; P/F = PaO2/FiO2; G-CSF = granulocyte colony-stimulating factor.