Table 6 Univariate factors associated with 90-day mortality in patients with AML.
Characteristic | 90-Day Status | p-value | |
|---|---|---|---|
| Â | Dead (n = 25) | Alive (n = 20) | Â |
Age (mean [SD]) | 59.4 (11.7) | 49.8 (12.9) | 0.01 |
≥ 2 co-morbidities (%) | 12 (52.2) | 9 (40.9) | 0.55 |
AML M1 Subtype (%) | 12 (48.0) | 3 (15.0) | 0.03 |
Poor cytogenetic profile (%) | 6 (26.1) | 7 (31.8) | 0.75 |
Time from AML diagnosis to ICU (d) | 65 (12-288) | 40 (9-95) | 0.61 |
Relapse/refractory AML status (%) | 8 (32.0) | 5 (25.0) | 0.75 |
Duration of neutropenia (d) (med [IQR]) | 15 (13-19) | 15 (13-19) | 0.80 |
Chemotherapy in ICU (%) | 1 (4.0) | 6 (30.0) | 0.03 |
Sepsis diagnosis (%) | 8 (32.0) | 6 (33.3) | 1.0 |
APACHE II score (mean [SD]) | 32.4 (10.7) | 28.0 (9.5) | 0.15 |
SOFA score (mean [SD]) | 14.6 (4.3) | 11.4 (3.3) | 0.007 |
Delta SOFA (day 1) (med [IQR]) | 1 (0 to 3) | 0 (-2 to 2) | 0.02 |
Delta SOFA (day 3) (med [IQR]) | 2 (-1 to 4) | -2 (-4 to 2) | 0.02 |
SOFA (maximum) (mean [SD]) | 12.1 (5.3) | 10.8 (3.1) | 0.46 |
MAP <60 mmHg (%) | 11 (44.0) | 4 (22.2) | 0.20 |
Lactate (mmol/L) (mean [SD]) | 4.1 (4.6) | 2.1 (1.7) | 0.08 |
Vasoactive therapy (%) | 22 (88.0) | 12 (60.0) | 0.04 |
Shock (%) | 25 (100) | 13 (72.2) | 0.009 |
Platelets (10 9 cells/L) (med [IQR]) | 17 (9-37) | 14 (10-31) | 0.90 |
Bilirubin (μmol/L) (mean [SD]) | 40.5 (37.3) | 31.1 (15.7) | 0.30 |
P/F ratio (mean [SD]) | 116 (88) | 149 (100) | < 0.001 |
Mechanical ventilation (%) | 21 (84.0) | 9 (45.0) | 0.01 |
Creatinine (μmol/L) (mean [SD]) | 148 (59) | 176 (108) | 0.28 |
Renal replacement therapy (%) | 7 (28.0) | 5 (25.0) | 1.0 |
G-CSF (%) | 17 (68.0) | 9 (47.4) | 0.22 |
Corticosteroids (%) | 13 (52.0) | 9 (47.4) | 1.0 |
Withdrawal of support (%) | 16 (64.0) | 0 (0) | < 0.001 |