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Table 3 Summary of ICU admission characteristics, acute physiology, and laboratory parameters stratified by AML status.

From: Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study

Variable

Total

(n = 275)

AML ICU Cases

(n = 45)

Non-AML ICU Controls

(n = 225)

p-value

Admission diagnostic category (%)§

    

   Sepsis/Infectious

53 (19.8)

14 (32.6)

39 (17.3)

0.04

   Respiratory

70 (26.1)

16 (37.2)

54 (24.0)

0.09

   Genitourinary

7 (2.6)

0 (0)

7 (3.1)

0.60

   Gastrointestinal

50 (18.7)

1 (2.3)

49 (21.8)

0.001

   Cardiovascular

27 (10.1)

1 (2.3)

26 (11.6)

0.09

   Neurologic

15 (5.6)

2 (4.7)

13 (5.8)

1.0

   Endocrine/Metabolic

13 (4.9)

0 (0)

13 (5.8)

0.14

   Trauma

22 (8.2)

0 (0)

22 (9.8)

0.03

   Other

11 (4.1)

9 (20.9)

2 (0.9)

< 0.001

APACHE II score (mean [SD])

29.1 (9.9)

30.3 (10.3)

28.9 (9.9)

0.39

   APACHE II score > 25 (%)

185 (68.5)

35 (77.8)

150 (66.7)

0.16

SOFA score (mean [SD])

11.7 (4.6)

12.6 (4.0)

10.8 (4.9)

0.05

   SOFA score > 11 (%)

55 (57.9)

32 (71.1)

23 (46.0)

0.02

Mechanical ventilation (%)

225 (83.3)

30 (66.7)

195 (86.7)

0.003

Acute physiology

    

   GCS (mean [SD])

7.6 (3.4)

5.9 (3.4)

7.9 (3.3)

0.0003

   Temperaturemax (mean [SD]) (degrees C)

37.4 (3.6)

38.4 (1.2)

37.2 (3.8)

0.05

   Heart ratemax (mean [SD]) (/min)

118 (23.4)

128 (18)

116 (24)

0.001

   Respiratory ratemax (mean [SD]) (/min)

28 (8)

34 (8)

26 (8)

< 0.0001

   Mean arterial pressuremin (mean [SD]) (mmHg)

59 (17)

60 (17)

59 (17)

0.74

Laboratory parameters

    

   Hematocrit (mean [SD])

26.6 (6.7)

22.6 (5.0)

27.3 (6.7)

< 0.0001

   White blood cell count (med [IQR]) (109 cells/mL)

7.8 (4.2-13.1)

0.6 (0.2-7.5)

9.1 (4.8-13.6)

< 0.0001

   Bilirubin (med [IQR]) (μmol/L)

23 (14-49)

33 (19-48)

22 (13-52)

0.26

   PaO2/FiO2 ratio (mean [SD])

174 (97)

158 (85)

177 (99)

0.22

   pH (mean [SD])

7.25 (0.15)

7.30 (0.13)

7.24 (0.15)

0.03

   Serum Sodium (mean [SD]) (mmol/L)

137 (6.0)

137 (7.0)

137 (5.8)

0.63

   Serum Creatinine (med [IQR) (μmol/L)

168 (93-284)

145 (97-203)

170 (89-318)

0.13

   Urine output (med [IQR]) (L/24 hr)

1.3 (0.4-2.5)

2.2 (1.0-3.1)

1.2 (0.4-2.4)

0.0006

Urine output <400 mL (%)

61 (22.9)

3 (7.0)

58 (25.9)

0.005

   Acute kidney injury (%)

138 (52.7)

23 (53.5)

115 (52.5)

1.0

  1. Abbreviations: SOFA = sequential organ failure assessment; APACHE = acute physiology and chronic health evaluation; GCS = Glasgow coma score; ANC = absolute neutrophil count
  2. § Sum exceeds 100% due to more than one primary diagnosis.
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