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Table 3 Summary of ICU admission characteristics, acute physiology, and laboratory parameters stratified by AML status.

From: Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study

Variable Total
(n = 275)
AML ICU Cases
(n = 45)
Non-AML ICU Controls
(n = 225)
p-value
Admission diagnostic category (%)§     
   Sepsis/Infectious 53 (19.8) 14 (32.6) 39 (17.3) 0.04
   Respiratory 70 (26.1) 16 (37.2) 54 (24.0) 0.09
   Genitourinary 7 (2.6) 0 (0) 7 (3.1) 0.60
   Gastrointestinal 50 (18.7) 1 (2.3) 49 (21.8) 0.001
   Cardiovascular 27 (10.1) 1 (2.3) 26 (11.6) 0.09
   Neurologic 15 (5.6) 2 (4.7) 13 (5.8) 1.0
   Endocrine/Metabolic 13 (4.9) 0 (0) 13 (5.8) 0.14
   Trauma 22 (8.2) 0 (0) 22 (9.8) 0.03
   Other 11 (4.1) 9 (20.9) 2 (0.9) < 0.001
APACHE II score (mean [SD]) 29.1 (9.9) 30.3 (10.3) 28.9 (9.9) 0.39
   APACHE II score > 25 (%) 185 (68.5) 35 (77.8) 150 (66.7) 0.16
SOFA score (mean [SD]) 11.7 (4.6) 12.6 (4.0) 10.8 (4.9) 0.05
   SOFA score > 11 (%) 55 (57.9) 32 (71.1) 23 (46.0) 0.02
Mechanical ventilation (%) 225 (83.3) 30 (66.7) 195 (86.7) 0.003
Acute physiology     
   GCS (mean [SD]) 7.6 (3.4) 5.9 (3.4) 7.9 (3.3) 0.0003
   Temperaturemax (mean [SD]) (degrees C) 37.4 (3.6) 38.4 (1.2) 37.2 (3.8) 0.05
   Heart ratemax (mean [SD]) (/min) 118 (23.4) 128 (18) 116 (24) 0.001
   Respiratory ratemax (mean [SD]) (/min) 28 (8) 34 (8) 26 (8) < 0.0001
   Mean arterial pressuremin (mean [SD]) (mmHg) 59 (17) 60 (17) 59 (17) 0.74
Laboratory parameters     
   Hematocrit (mean [SD]) 26.6 (6.7) 22.6 (5.0) 27.3 (6.7) < 0.0001
   White blood cell count (med [IQR]) (109 cells/mL) 7.8 (4.2-13.1) 0.6 (0.2-7.5) 9.1 (4.8-13.6) < 0.0001
   Bilirubin (med [IQR]) (μmol/L) 23 (14-49) 33 (19-48) 22 (13-52) 0.26
   PaO2/FiO2 ratio (mean [SD]) 174 (97) 158 (85) 177 (99) 0.22
   pH (mean [SD]) 7.25 (0.15) 7.30 (0.13) 7.24 (0.15) 0.03
   Serum Sodium (mean [SD]) (mmol/L) 137 (6.0) 137 (7.0) 137 (5.8) 0.63
   Serum Creatinine (med [IQR) (μmol/L) 168 (93-284) 145 (97-203) 170 (89-318) 0.13
   Urine output (med [IQR]) (L/24 hr) 1.3 (0.4-2.5) 2.2 (1.0-3.1) 1.2 (0.4-2.4) 0.0006
Urine output <400 mL (%) 61 (22.9) 3 (7.0) 58 (25.9) 0.005
   Acute kidney injury (%) 138 (52.7) 23 (53.5) 115 (52.5) 1.0
  1. Abbreviations: SOFA = sequential organ failure assessment; APACHE = acute physiology and chronic health evaluation; GCS = Glasgow coma score; ANC = absolute neutrophil count
  2. § Sum exceeds 100% due to more than one primary diagnosis.