Variable | Total (n = 95) | AML ICU Cases (n = 45) | AML non-ICU Controls (n = 50) | p-value |
---|---|---|---|---|
AML WHO classification (n = 91) | Â | Â | Â | Â |
   AML with recurrent genetic abnormalities | 44 (46.3) | 19 (42.2) | 25 (50.0) | 0.18 |
   AML with multi-lineage dysplasia | 17 (17.9) | 10 (22.2) | 7 (14.0) |  |
   AML and myelodysplastic syndromes, therapy-related | 6 (6.3) | 5 (11.1) | 1 (2.0) |  |
   AML not otherwise categorized | 28 (29.5) | 11 (24.4) | 17 (34.0) |  |
AML FAB Classification (n = 71) | Â | Â | Â | Â |
   M0 | 4 (4.2) | 0 (0) | 4 (8.0) | 0.12 |
   M1 | 28 (29.5) | 15 (33.3) | 13 (26.0) |  |
   M2 | 20 (21.1) | 11 (24.4) | 9 (18.0) |  |
   M3 | 12 (12.6) | 3 (6.7) | 9 (18.0) |  |
   M4 | 12 (12.6) | 4 (8.9) | 8 (16.0) |  |
   M4eo | 5 (5.3) | 4 (8.9) | 1 (2.0) |  |
   M5 | 13 (13.7) | 7 (15.6) | 6 (12.0) |  |
   M6 | 1 (1.1) | 1 (2.2) | 0 (0) |  |
Cytogenetic prognosis § (%) |  |  |  |  |
   Good | 13 (13.7) | 6 (13.3) | 7 (14.0) | 0.96 |
   Intermediate | 38 (40.0) | 17 (37.8) | 21 (42.0) |  |
   Poor | 14 (28.0) | 13 (28.9) | 14 (28.0) |  |
   Unknown/not available | 8 (16.0) | 9 (20.0) | 8 (16.0) |  |
Complete blood count at diagnosis: | Â | Â | Â | Â |
   Hemoglobin (g/L) | 96.7 (22.1) | 95.9 (21.6) | 97.3 22.6) | 0.76 |
   Platelets (cells/109) | 46 (26-96) | 45 (31-96) | 47 (24-96) | 0.46 |
White cell count (WBC) (cells/10 9 ) | 8.2 (2.3-50.6) | 7.7 (2.0-50.8) | 16.0 (3.2-42.9) | 0.87 |
   WBC < 1 (%) | 6 (7.1) | 3 (6.7) | 3 (6.0) | 1.0 |
   WBC > 25 (%) | 34 (35.8) | 15 (33.3) | 19 (38.0) | 0.67 |
Duration of Neutropenia (days) (mean [SD]) | 14.1 (14.3) | 13.1 (14.4) | 15.2 (14.2) | 0.48 |
Bone marrow blast count (%) | 56.6 (23.7) | 52.9 (23.7) | 60.1 (23.5) | 0.15 |
   Blasts >20% | 86 (94.5) | 41 (93.2) | 45 (95.7) | 0.67 |
AML Status | Â | Â | Â | Â |
   Newly diagnosed/active disease | 58 (61.1) | 24 (53.3) | 34 (68.0) | 0.01 |
   Refractory/relapse | 29 (30.5) | 13 (28.9) | 16 (32.0) |  |
   BMT/remission | 4 (4.2) | 4 (8.9) | 0 (0) |  |
   Remission | 4 (4.2) | 4 (8.9) | 0 (0) |  |
Therapeutic Regimen | Â | Â | Â | Â |
   Intensive/induction chemotherapy | 78 (82.1) | 38 (84.4) | 40 (80.0) | 0.60 |
   Cytoreductive/palliative | 17 (17.9) | 7 (15.6) | 10 (20.0) |  |