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Table 2 Summary of diagnostic characteristics of AML.

From: Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study

Variable Total
(n = 95)
AML ICU Cases
(n = 45)
AML non-ICU Controls
(n = 50)
p-value
AML WHO classification (n = 91)     
   AML with recurrent genetic abnormalities 44 (46.3) 19 (42.2) 25 (50.0) 0.18
   AML with multi-lineage dysplasia 17 (17.9) 10 (22.2) 7 (14.0)  
   AML and myelodysplastic syndromes, therapy-related 6 (6.3) 5 (11.1) 1 (2.0)  
   AML not otherwise categorized 28 (29.5) 11 (24.4) 17 (34.0)  
AML FAB Classification (n = 71)     
   M0 4 (4.2) 0 (0) 4 (8.0) 0.12
   M1 28 (29.5) 15 (33.3) 13 (26.0)  
   M2 20 (21.1) 11 (24.4) 9 (18.0)  
   M3 12 (12.6) 3 (6.7) 9 (18.0)  
   M4 12 (12.6) 4 (8.9) 8 (16.0)  
   M4eo 5 (5.3) 4 (8.9) 1 (2.0)  
   M5 13 (13.7) 7 (15.6) 6 (12.0)  
   M6 1 (1.1) 1 (2.2) 0 (0)  
Cytogenetic prognosis § (%)     
   Good 13 (13.7) 6 (13.3) 7 (14.0) 0.96
   Intermediate 38 (40.0) 17 (37.8) 21 (42.0)  
   Poor 14 (28.0) 13 (28.9) 14 (28.0)  
   Unknown/not available 8 (16.0) 9 (20.0) 8 (16.0)  
Complete blood count at diagnosis:     
   Hemoglobin (g/L) 96.7 (22.1) 95.9 (21.6) 97.3 22.6) 0.76
   Platelets (cells/109) 46 (26-96) 45 (31-96) 47 (24-96) 0.46
White cell count (WBC) (cells/10 9 ) 8.2 (2.3-50.6) 7.7 (2.0-50.8) 16.0 (3.2-42.9) 0.87
   WBC < 1 (%) 6 (7.1) 3 (6.7) 3 (6.0) 1.0
   WBC > 25 (%) 34 (35.8) 15 (33.3) 19 (38.0) 0.67
Duration of Neutropenia (days) (mean [SD]) 14.1 (14.3) 13.1 (14.4) 15.2 (14.2) 0.48
Bone marrow blast count (%) 56.6 (23.7) 52.9 (23.7) 60.1 (23.5) 0.15
   Blasts >20% 86 (94.5) 41 (93.2) 45 (95.7) 0.67
AML Status     
   Newly diagnosed/active disease 58 (61.1) 24 (53.3) 34 (68.0) 0.01
   Refractory/relapse 29 (30.5) 13 (28.9) 16 (32.0)  
   BMT/remission 4 (4.2) 4 (8.9) 0 (0)  
   Remission 4 (4.2) 4 (8.9) 0 (0)  
Therapeutic Regimen     
   Intensive/induction chemotherapy 78 (82.1) 38 (84.4) 40 (80.0) 0.60
   Cytoreductive/palliative 17 (17.9) 7 (15.6) 10 (20.0)  
  1. Abbreviations: WHO = World Health Organization; FAB = French American British; WBC = white blood cell count
  2. § Cytogenetic Prognosis: Good = t(8;21); t(15;17); inv16 or t(16;16); Intermediate = normal; trisomy 8; 11q23 abnormality; Poor = deletion of chromosome 5 or 5q; deletion of chromosome 7 or 7q; 3q abnormality; complex; Unknown = significance not known; no cytogenetic information.