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Table 1 Clinicopathologic characteristics of breast cancer subtypes

From: Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

    Molecular Subtyping   
  All        Five subtypes Four subtypes P value between five subtypes *,† P value between four subtypes **,†
Variables    IHC-Luminal A IHC-Luminal B IHC-HER2 IHC-BLBC IHC-QNBC/5NP IHC-TNBC   
  N = 951 N = 486
51.1%
N = 123
12.9%
N = 113
11.9%
N = 139
14.6%
N = 90
9.5%
N = 229
24.1%
  
  No. (%) No. (%) No. (%) No. (%) No. (%) No. (%) No. (%)   
Age Group (years)                < 0.001 < 0.001
   > 50 590 62.0 297 61.1 87 70.7 51 45.1 97 69.8 58 64.4 155 67.7   
   ≥ 50 361 38.0 189 38.9 36 29.3 62 54.9 42 30.2 32 35.6 74 32.3   
Family history of breast cancer                0.006 0.086
   No 916 96.3 470 96.7 121 98.4 111 98.2 126 90.6 88 97.8 214 93.4   
   Yes 35 3.7 16 3.3 2 1.6 2 1.8 13 9.4 2 2.2 15 6.6   
Tumor Size                0.014 0.006
   ≤ 2 cm 392 41.2 228 46.9 39 31.7 35 31.0 52 37.4 38 42.2 90 39.3   
   2-5 cm 493 51.8 231 47.5 75 61.0 64 56.6 76 54.7 47 52.2 123 53.7   
   > 5 cm 66 6.9 27 5.6 9 7.3 14 12.4 11 7.9 5 5.6 16 7.0   
N Staging                0.178 0.014
   N0 498 52.4 246 50.6 52 42.3 63 55.8 89 64.0 48 53.3 137 59.8   
   N1 247 25.9 131 27.0 40 32.5 22 19.5 31 22.3 23 25.6 54 23.6   
   N2 118 12.4 64 13.2 19 15.4 13 11.5 12 8.6 10 11.1 22 9.6   
   N3 88 9.2 45 9.3 12 9.8 15 13.3 7 5.0 9 10.0 16 7.0   
AJCC stage                0.014 0.008
   I 254 26.7 148 30.5 19 15.4 22 19.5 38 27.3 27 30.0 65 28.4   
   II 467 49.1 221 45.5 69 56.1 57 5.04 78 56.1 42 46.7 120 52.4   
   III 230 24.2 117 24.1 35 28.5 34 30.1 23 16.5 21 23.3 44 19.2   
LN involvement                0.016 0.020
   Negative 498 52.4 246 50.6 52 42.3 63 55.8 89 64.0 48 53.3 137 59.8   
   Positive 453 47.6 240 49.4 71 57.7 50 44.2 50 36.0 42 46.7 92 40.2   
Nuclear Grade                < 0.001 < 0.001
   Low 92 9.7 67 13.8 5 4.1 3 2.7 9 6.5 8 8.8 17 7.4   
   Intermediate 486 51.1 308 63.4 65 52.8 40 35.4 26 18.7 47 52.2 73 31.9   
   High 373 39.2 111 22.8 53 43.1 70 61.9 104 74.8 35 38.9 139 60.7   
Histological Grade                < 0.001 < 0.001
   Well 100 10.5 63 13.0 10 8.1 11 9.7 8 5.8 8 8.9 16 7.0   
   Moderate 597 62.8 334 68.7 76 61.8 65 57.5 71 51.1 51 56.7 122 53.3   
   Poor 254 26.7 89 18.3 37 30.1 37 32.7 60 43.2 31 34.4 91 39.7   
Estrogen Receptor (ER)                < 0.001 < 0.001
   Negative 364 38.3 11 2.3 11 8.9 113 100.0 139 100.0 90 100.0 229 100.0   
   Positive 587 61.7 475 97.7 112 91.1 0 0.0 0 0.0 0 0.0 0 0.0   
Progesterone Receptor (PR)                < 0.001 < 0.001
   Negative 522 54.9 143 29.4 37 30.1 113 100.0 139 100.0 90 100.0 229 100.0   
   Positive 429 45.1 343 70.6 86 69.9 0 0.0 0 0.0 0 0.0 0 0.0   
HER2                 
   Negative 715 75.2 486 100.0 0 0.0 0 0.0 139 100.0 90 100.0 229 100.0   
   Positive 236 24.8 0 0.0 123 100.0 113 100.0 0 0.0 0 0.0 0 0.0   
CK 5/6                 
   Negative 820 86.2 474 97.7 123 100.0 103 91.2 30 21.6 90 100.0 120 52.4   
   Positive 131 13.8 12 2.5 0 0.0 10 8.8 109 78.4 0 0.0 109 47.6   
EGFR                 
   Negative 821 86.3 471 96.9 119 96.7 92 81.4 49 35.3 90 100.0 139 60.7   
   Positive 130 13.7 15 3.1 4 3.3 21 18.6 90 64.7 0 0.0 90 39.3   
Histological type                 
   Invasive ductal carcinoma 872 91.6 438 90.1 122 99.2 106 93.8 125 89.9 81 90.0 206 90.0   
   Invasive lobular carcinoma 26 2.7 22 4.5        4 4.4 4 1.7   
   Mucinous carcinoma 13 1.4 10 2.1    2 1.8    1 1.1 1 0.4   
   Invasive papillary carcinoma 8 0.8 5 1.0 1 0.8    2 1.4    2 0.9   
   Medullary carcinoma 10 1.1 1 0.2    1 0.9 8 5.8    8 3.5   
   Metaplastic carcinoma 6 0.6 1 0.2      3 2.2 2 2.2 5 2.2   
   Others 18 1.6 9 1.9    3 2.7         
Operation                 
   BCS 359 37.7 200 41.2 40 32.5 30 26.5 58 41.7 31 34.4 89 38.9 0.048 0.038
   Mastectomy 592 62.3 286 58.8 83 67.5 83 73.5 81 58.3 59 65.6 140 61.1   
Adjuvant chemotherapy                 
   Not done 155 16.3 95 19.5 20 16.3 22 19.5 10 7.2 8 8.9 18 7.9 0.004 0.002
   Done 796 83.7 391 80.5 103 83.7 91 80.5 129 92.8 82 91.1 211 92.1   
Anthracycline 292 36.7 156 39.9 40 38.8 33 36.3 34 11.6 29 35.4 63 29.9 0.101 0.114
CMF 491 61.7 229 58.6 61 59.2 58 63.7 92 71.3 51 62.2 143 67.8   
Others 13 1.6 6 1.5 2 1.9 0 0 3 2.3 2 2.4 5 2.4   
Radiation therapy                 
   Not done 503 52.9 250 51.4 73 59.3 63 55.8 69 49.6 48 53.3 117 51.1 1.0 1.0
   Done 448 47.1 236 48.6 50 40.7 50 44.2 70 50.4 42 46.7 112 48.9   
  1. * Five subtypes are Luminal A, Luminal B, HER2+, BLBC, and QNBC
  2. ** Four subtypes are Luminal A, Luminal B, HER2+-, and TNBC
  3. † Chi-square test using Bonferroni's correction
  4. IHC: immunohistochemistry