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Table 2 Dysregulated genes following overexpression of miR-183

From: Dysregulated miR-183 inhibits migration in breast cancer cells

Gene Dysregulation
(%)
Function Putative Target
CAV1 73.12 Tumor suppressor gene candidate. Codes for scaffolding protein No miRBase
No Pictar
NoTargetscan
CD68 70.51 Phagocytosis No miRBase
No Pictar
NoTargetscan
CASP2 67.16 Apoptosis Yes miRBase
No Pictar
Yes Targetscan
BAG3 57.70 Negative regulator of apoptosis, adhesion, migration Yes miRBase
No Pictar
No Targetscan
TPM1 57.53 Actin-binding. Stabilizes cytoskeleton actin filaments No miRBase
No Pictar
Yes Targetscan
BRCA1 57.21 Tumor suppressor, DNA repair No miRBase
No Pictar
No Targetscan
NCOA4 56.08 Ligand-independent coactivator of PPAR-gamma No miRBase
No Pictar
Yes Targetscan
**VIL2 54.51 Linker between plasma membrane and actin cytoskeleton, involved in cell adhesion & migration. Yes miRBase
Yes Pictar
Yes targetscan
SNCG 53.69 Role in neurofilament network integrity. No miRBase
No Pictar
No Targetscan
EPHA2 53.15 Receptor for members of the ephrin-A family No miRBase
No Pictar
Yes Targetscan
MYBL2 52.82 Transcription factor involved in the regulation of cell survival, proliferation, and differentiation No miRBase
No Pictar
No Targetscan
KRAS 52.30 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity No miRBase
No Pictar
No Targetscan
FYN 50.91 Implicated in the control of cell growth No miRBase
No Pictar
No Targetscan
FGFR4 -58.97 Implicated in cell growth, proliferation. No miRBase
No Pictar
No Targetscan