Table 2 Dysregulated genes following overexpression of miR-183
From: Dysregulated miR-183 inhibits migration in breast cancer cells
Gene | Dysregulation (%) | Function | Putative Target |
|---|---|---|---|
CAV1 | 73.12 | Tumor suppressor gene candidate. Codes for scaffolding protein | No miRBase No Pictar NoTargetscan |
CD68 | 70.51 | Phagocytosis | No miRBase No Pictar NoTargetscan |
CASP2 | 67.16 | Apoptosis | Yes miRBase No Pictar Yes Targetscan |
BAG3 | 57.70 | Negative regulator of apoptosis, adhesion, migration | Yes miRBase No Pictar No Targetscan |
TPM1 | 57.53 | Actin-binding. Stabilizes cytoskeleton actin filaments | No miRBase No Pictar Yes Targetscan |
BRCA1 | 57.21 | Tumor suppressor, DNA repair | No miRBase No Pictar No Targetscan |
NCOA4 | 56.08 | Ligand-independent coactivator of PPAR-gamma | No miRBase No Pictar Yes Targetscan |
**VIL2 | 54.51 | Linker between plasma membrane and actin cytoskeleton, involved in cell adhesion & migration. | Yes miRBase Yes Pictar Yes targetscan |
SNCG | 53.69 | Role in neurofilament network integrity. | No miRBase No Pictar No Targetscan |
EPHA2 | 53.15 | Receptor for members of the ephrin-A family | No miRBase No Pictar Yes Targetscan |
MYBL2 | 52.82 | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation | No miRBase No Pictar No Targetscan |
KRAS | 52.30 | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | No miRBase No Pictar No Targetscan |
FYN | 50.91 | Implicated in the control of cell growth | No miRBase No Pictar No Targetscan |
FGFR4 | -58.97 | Implicated in cell growth, proliferation. | No miRBase No Pictar No Targetscan |