Table 2 Cox univariate and multivariate analysis of the relative risks for death and recurrent disease according to TATI serum levels.
Relative risk for death in all patients (Overall survival) | Relative risk for second cancer, recurrence or death to any cause in curatively treated patients (Disease free survival) | |||||
|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||
n* | HR (95% CI) | HR (95% CI) | n | HR (95% CI) | HR (95% CI) | |
Age at operation | ||||||
Age <75 years | 180 | 1.0 (ref) | 1.0 (ref) | 148 | 1.0 (ref) | 1.0 (ref) |
Age ≥75 years | 129 | 1.88(1.34-2.62) | 2.23(1.55-3.23) | 116 | 2.00(1.39-2.86) | 1.94(1.30-2.87) |
Gender | ||||||
Female | 161 | 1.0 (ref) | 1.0 (ref) | 134 | 1.0 (ref) | 1.0 (ref) |
Male | 164 | 0.86(0.62-1.18) | 0.82(0.58-1.16) | 136 | 0.84(0.59-1.20) | 0.82(0.57-1.19) |
Disease stage | ||||||
Stage I | 44 | 1.0 (ref) | 1.0 (ref) | 44 | 1.0 (ref) | 1.0 (ref) |
Stage II | 134 | 0.95(0.52-1.74) | 1.07(0.57-2.01) | 132 | 1.36(0.75-2.45) | 1.47(0.79-2.70) |
Stage III | 96 | 1.84(1.02-3.34) | 1.94(1.04-3.65) | 92 | 2.25(1.25-4.06) | 2.27(1.21-4.24) |
Stage IV | 47 | 7.62(4.11-14.16) | 6.88(3.43-13.82) | 0 | N/A | N/A |
Differentiation grade | ||||||
High-moderate | 251 | 1.0 (ref) | 1.0 (ref) | 215 | 1.0 (ref) | 1.0 (ref) |
Poor | 70 | 1.55(1.07-2.25) | 1.38(0.92-2.07) | 55 | 1.31(0.86-2.00) | 1.31(0.85-2.02) |
Vascular invasion | ||||||
No invasion | 271 | 1.0 (ref) | 1.0 (ref) | 243 | 1.0 (ref) | 1.0 (ref) |
Invasion | 38 | 2.24(1.45-3.46) | 1.29(0.80-2.08) | 21 | 1.67(0.94-2.98) | 1.52(0.83-2.78) |
s-CEA | ||||||
< 2,67 μg/L | 159 | 1.0 (ref) | 1.0 (ref) | 146 | 1.0 (ref) | 1.0 (ref) |
≥2,67 μg/L | 165 | 2.05(1.47-2.87) | 1.60(1.11-2.32) | 124 | 1.56(1.10-2.23) | 1.59(1.10-2.32) |
s-TATI | ||||||
< 15,59 μg/L | 159 | 1.0 (ref) | 1.0 (ref) | 165 | 1.0 (ref) | 1.0 (ref) |
≥15,59 μg/L | 165 | 2.40(1.74-3.33) | 1.78(1.25-2.53) | 105 | 2.00(1.40-2.84) | 1.51(1.03-2.22) |
t-TATI | ||||||
≤50% cells | 233 | 1.0 (ref) | 1.0 (ref) | 196 | 1.0 (ref) | 1.0 (ref) |
> 50% cells | 65 | 1.40(0.96-2.05) | 1.25(0.85-1.86) | 58 | 1.67(1.12-2.49) | 1.56(1.04-2.34) |