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Table 4 VDR, CYP27B1 and CYP24A1 and other breast cancer biomarkers expression in invasive breast tumours

From: Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions

  

VDR

CYP27B1

CYP24A1

  

+ (%)

- (%)

+ (%)

- (%)

+ (%)

- (%)

ER

+ (%)

114 (37.3)

60 (19.6)

70 (25.4)

86 (31.2)

93 (33.1)

66 (23.5)

 

- (%)

58 (19.0)

74 (24.2)

53 (19.2)

67 (24.3)

58 (20.6)

64 (22.8)

 

p value

0.0002

ns

ns

HER2

+ (%)

26 (8.6)

34 (11.3)

31 (11.4)

25 (9.2)

29 (10.4)

30 (10.8)

 

- (%)

144 (47.7)

98 (32.5)

90 (33.1)

126 (46.3)

121 (43.5)

98 (35.3)

 

p value

0.0238

ns

ns

PgR

+ (%)

71 (23.3)

59 (19.3)

52 (18.8)

64 (23.2)

71 (25.3)

46 (16.4)

 

- (%)

100 (32.8)

75 (24.6)

71 (25.7)

89 (32.2)

80 (28.5)

84 (29.9)

 

p value

ns

ns

0.0485

CK5

+ (%)

27 (8.8)

19 (6.2)

15 (5.4)

24 (8.7)

27 (9.6)

16 (5.7)

 

- (%)

145 (47.4)

115 (37.6)

108 (39.1)

129 (46.7)

124 (44.1)

114 (40.6)

 

p value

ns

ns

ns

EGFR

+ (%)

4 (1.3)

7 (2.3)

4 (1.5)

6 (2.2)

6 (2.1)

3 (1.1)

 

- (%)

166 (54.8)

126 (41.6)

118 (43.1)

146 (53.3)

145 (51.8)

126 (45.0)

 

p value

ns

ns

ns

P-cad

+ (%)

42 (13.8)

40 (13.1)

30 (10.9)

42 (15.2)

40 (14.3)

37 (13.2)

 

- (%)

129 (42.3)

94 (30.8)

93 (33.7)

111 (40.2)

110 (39.3)

93 (33.2)

 

p value

ns

ns

ns

  1. ns: not significant.