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Table 4 VDR, CYP27B1 and CYP24A1 and other breast cancer biomarkers expression in invasive breast tumours

From: Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions

   VDR CYP27B1 CYP24A1
   + (%) - (%) + (%) - (%) + (%) - (%)
ER + (%) 114 (37.3) 60 (19.6) 70 (25.4) 86 (31.2) 93 (33.1) 66 (23.5)
  - (%) 58 (19.0) 74 (24.2) 53 (19.2) 67 (24.3) 58 (20.6) 64 (22.8)
  p value 0.0002 ns ns
HER2 + (%) 26 (8.6) 34 (11.3) 31 (11.4) 25 (9.2) 29 (10.4) 30 (10.8)
  - (%) 144 (47.7) 98 (32.5) 90 (33.1) 126 (46.3) 121 (43.5) 98 (35.3)
  p value 0.0238 ns ns
PgR + (%) 71 (23.3) 59 (19.3) 52 (18.8) 64 (23.2) 71 (25.3) 46 (16.4)
  - (%) 100 (32.8) 75 (24.6) 71 (25.7) 89 (32.2) 80 (28.5) 84 (29.9)
  p value ns ns 0.0485
CK5 + (%) 27 (8.8) 19 (6.2) 15 (5.4) 24 (8.7) 27 (9.6) 16 (5.7)
  - (%) 145 (47.4) 115 (37.6) 108 (39.1) 129 (46.7) 124 (44.1) 114 (40.6)
  p value ns ns ns
EGFR + (%) 4 (1.3) 7 (2.3) 4 (1.5) 6 (2.2) 6 (2.1) 3 (1.1)
  - (%) 166 (54.8) 126 (41.6) 118 (43.1) 146 (53.3) 145 (51.8) 126 (45.0)
  p value ns ns ns
P-cad + (%) 42 (13.8) 40 (13.1) 30 (10.9) 42 (15.2) 40 (14.3) 37 (13.2)
  - (%) 129 (42.3) 94 (30.8) 93 (33.7) 111 (40.2) 110 (39.3) 93 (33.2)
  p value ns ns ns
  1. ns: not significant.
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