From: Internal mammary lymph node recurrence: rare but characteristic metastasis site in breast cancer
Factors | N | Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|---|---|
 |  | Median (m) | p-value | HR | 95% CI | p-value |
Menopausal stastus | Â | Â | 0.773 | NS | ||
   Premenopausal | 55 | 33 |  |  |  |  |
   Postmenopausal | 78 | 42 |  |  |  |  |
Primary tumor location | Â | Â | 0.837 | NS | ||
   Areola and inner area | 61 | 38 |  |  |  |  |
   Outer area | 72 | 40 |  |  |  |  |
Tumor size(cm) | Â | Â | 0.008* | 0.5 | 0.4- 0.8 | 0.002* |
   ≤2 | 42 | 49 |  |  |  |  |
   >2 | 91 | 33 |  |  |  |  |
Axillary lymph node | Â | Â | 0.070 | NS | ||
   negative | 62 | 43 |  |  |  |  |
   positive | 71 | 33 |  |  |  |  |
TNM stage | Â | Â | 0.390 | NS | ||
   I - II | 104 | 38 |  |  |  |  |
   III | 29 | 29 |  |  |  |  |
ER/PR status | Â | Â | 0.020* | 0.6 | 0.4- 0.9 | 0.006* |
   Positive | 78 | 50 |  |  |  |  |
   Negative | 55 | 32 |  |  |  |  |
HER-2 status | Â | Â | 0.193 | NS | ||
   Positive | 29 | 26 |  |  |  |  |
   Negative | 104 | 42 |  |  |  |  |
Adjuvant chemotherapy | Â | Â | 0.113 | NS | ||
   Yes | 124 | 36 |  |  |  |  |
   No | 9 | 41 |  |  |  |  |
Adjuvant radiotherapy for T >5 cm | Â | Â | 0.018* | 0.9 | 0.6- 1.3 | 0.463 |
   Yes | 3 | 56 |  |  |  |  |
   No | 4 | 21 |  |  |  |  |
Adjuvant radiotherapy for ALN ≥4 |  |  | 0.949 | NS | ||
   Yes | 20 | 29 |  |  |  |  |
   No | 8 | 26 |  |  |  |  |