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Table 4 Odds ratios (OR)* and 95% confidence intervals (CI) for lung cancer risk according to CYP1A1 genotype groups and stratification by histological types.

From: CYP1A1gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study

 

*1/*1

*1/*2 a

*1/2B

*2B/*3

*1/*2C

*1/*4

*4/*4

*2A/*4

Controls, N (%)

189 (71.9)

44 (16.7)

8 (3.0)

22 (8.4)

All cases, N (%)

68 (66.7)

10 (9.8)

13 (12.7)

11 (10.8)

OR (CI)

1.0

0.51 (0.3-1.2)

4.51 (1.8-11.9)

1.29 (0.6-2.9)

p

 

0.18

< 0.01

0.29

Squamous-cell, N (%)

35 (71.4)

5 (10.2)

7 (14.3)

2 (4.1)

OR (CI)

1.0

0.51 (0.2-1.6)

5.01 (1.6-14.3)

0.49 (0.1-2.4)

p

 

0.37

< 0.01

0.40

Adenocarcinoma, N (%)

10 (66.7)

1 (6.7)

2 (13.3)

2 (13.3)

OR (CI)

1.0

0.41 (0.04-2.91))

4.71 (0.8-27.3)

1.62 (0.3-7.7)

p

 

0.51

0.10

0.65

SCLC, N (%)

9 (60)

-

2 (13.3)

4 (26.7)

OR (CI)

1.0

nc

6.97 (1.2-81.3)

8.33 (1.1-15.2)

p

 

nc

0.04

0.04

LCLC, N (%)

14 (60.9)

4 (17.4)

2 (8.7)

3 (13)

OR (CI)

1.0

1.01 (0.3-3.1)

2.7 (0.5-14.6)

1.68 (0.4-5.2)

p

 

1

0.24

0.75

  1. *ORs were adjusted for age, sex, and smoking (non/moderate/heavy), taking the CYP1A1*1/*1 genotype as reference. Genotype groups were generated as described in the Methods section.
  2. SCLC: Small-cell lung carcinoma.
  3. LCLC: Large-cell lung carcinoma.
  4. nc: non-calculable.