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Table 4 Odds ratios (OR)* and 95% confidence intervals (CI) for lung cancer risk according to CYP1A1 genotype groups and stratification by histological types.

From: CYP1A1gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study

  *1/*1 *1/*2 a *1/2B
*2B/*3
*1/*2C
*1/*4
*4/*4
*2A/*4
Controls, N (%) 189 (71.9) 44 (16.7) 8 (3.0) 22 (8.4)
All cases, N (%) 68 (66.7) 10 (9.8) 13 (12.7) 11 (10.8)
OR (CI) 1.0 0.51 (0.3-1.2) 4.51 (1.8-11.9) 1.29 (0.6-2.9)
p   0.18 < 0.01 0.29
Squamous-cell, N (%) 35 (71.4) 5 (10.2) 7 (14.3) 2 (4.1)
OR (CI) 1.0 0.51 (0.2-1.6) 5.01 (1.6-14.3) 0.49 (0.1-2.4)
p   0.37 < 0.01 0.40
Adenocarcinoma, N (%) 10 (66.7) 1 (6.7) 2 (13.3) 2 (13.3)
OR (CI) 1.0 0.41 (0.04-2.91)) 4.71 (0.8-27.3) 1.62 (0.3-7.7)
p   0.51 0.10 0.65
SCLC, N (%) 9 (60) - 2 (13.3) 4 (26.7)
OR (CI) 1.0 nc 6.97 (1.2-81.3) 8.33 (1.1-15.2)
p   nc 0.04 0.04
LCLC, N (%) 14 (60.9) 4 (17.4) 2 (8.7) 3 (13)
OR (CI) 1.0 1.01 (0.3-3.1) 2.7 (0.5-14.6) 1.68 (0.4-5.2)
p   1 0.24 0.75
  1. *ORs were adjusted for age, sex, and smoking (non/moderate/heavy), taking the CYP1A1*1/*1 genotype as reference. Genotype groups were generated as described in the Methods section.
  2. SCLC: Small-cell lung carcinoma.
  3. LCLC: Large-cell lung carcinoma.
  4. nc: non-calculable.