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Table 2 Multivariate analyses of the risk factors associated with ETR, tumor size, tumor stage, tumor grade, and survival of the patients with primary unifocal HCC

From: Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC

Covariate Variable Estimate SE Wald χ2 P OR
ETR (yes) a      
   Intercept -0.2071 1.1146 0.0345 0.8526 --
   Aurora B ↑* 1.543 0.4721 10.6826 0.0011 4.679
   Size 1.3177 0.4451 8.7658 0.0031 3.735
   Stage 1.2839 0.4789 7.1876 0.0073 3.611
   Age ≤55 0.0414 0.0184 5.0581 0.0245 1.043
Size b      
   Intercept -0.7535 0.4762 2.5037 0.1136 --
   p53 mutation 1.5197 0.4828 9.9073 0.0016 4.571
   Aurora A 1.1577 0.4937 5.48 0.0192 3.176
   HCV -1.0277 0.4958 4.2961 0.0382 0.358
   Cirrhosis -1.1187 0.4989 5.0291 0.0249 0.327
Stage III-IV c      
   Intercept -4.3949 1.1039 15.8508 < 0.0001 --
   Aurora B 2.0067 0.5516 13.2351 0.0003 7.439
   p53 mutation 1.0769 0.5399 3.9782 0.0461 2.936
   Grade 1.0442 0.3965 6.9351 0.0085 2.841
   Size 0.2495 0.0755 10.9173 0.001 1.283
Grade d      
   Intercept 0.4449 0.4037 1.2146 0.2704 --
   HBV 0.8776 0.3814 5.2947 0.0214 2.405
   p53 mutation 0.8058 0.3677 4.8033 0.0284 2.239
   AFP 0.8056 0.3808 4.4754 0.0344 2.238
   β-catenin mutation -1.4923 0.5578 7.1569 0.0075 0.225
Survival time      
   ETR 3.3735 0.5685 35.2186 < 0.0001 29.181
   Grade 0.4158 0.1448 8.2453 0.0041 1.516
   Size 0.0698 0.0247 7.9621 0.0048 1.072
  1. aLogistic regression model: n = 149, percentage of concordant pairs = 86.5%, percentage of discordant pairs = 13.3%, adjusted generalized R2 = 0.3755, Hosmer and Lemeshow goodness-of-fit test P = 0.4583 (degrees of freedom = 8).
  2. bLogistic regression model: n = 120, percentage of concordant pairs = 84.3%, percentage of discordant pairs = 14.4%, adjusted generalized R2 = 0.3507, Hosmer and Lemeshow goodness-of-fit test P = 0.3603 (degrees of freedom = 8).
  3. cLogistic regression model: n = 125, percentage of concordant pairs = 90.9%, percentage of discordant pairs = 8.9%, adjusted generalized R2 = 0.4647, Hosmer and Lemeshow goodness-of-fit test P = 0.7933 (degrees of freedom = 8).
  4. dLogistic regression model: n = 123, percentage of concordant pairs = 65.8%, percentage of discordant pairs = 21.6%, adjusted generalized R2 = 0.2291, Hosmer and Lemeshow goodness-of-fit test P = not applicable.
  5. *↑, mRNA overexpression