Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC

BMC Cancer

Table 2 Multivariate analyses of the risk factors associated with ETR, tumor size, tumor stage, tumor grade, and survival of the patients with primary unifocal HCC

Covariate	Variable Estimate	SE	Wald χ²	P	OR
ETR (yes) ^a
Intercept	-0.2071	1.1146	0.0345	0.8526	--
Aurora B ↑*	1.543	0.4721	10.6826	0.0011	4.679
Size	1.3177	0.4451	8.7658	0.0031	3.735
Stage	1.2839	0.4789	7.1876	0.0073	3.611
Age ≤55	0.0414	0.0184	5.0581	0.0245	1.043
Size ^b
Intercept	-0.7535	0.4762	2.5037	0.1136	--
p53 mutation	1.5197	0.4828	9.9073	0.0016	4.571
Aurora A ↑	1.1577	0.4937	5.48	0.0192	3.176
HCV	-1.0277	0.4958	4.2961	0.0382	0.358
Cirrhosis	-1.1187	0.4989	5.0291	0.0249	0.327
Stage III-IV ^c
Intercept	-4.3949	1.1039	15.8508	< 0.0001	--
Aurora B ↑	2.0067	0.5516	13.2351	0.0003	7.439
p53 mutation	1.0769	0.5399	3.9782	0.0461	2.936
Grade	1.0442	0.3965	6.9351	0.0085	2.841
Size	0.2495	0.0755	10.9173	0.001	1.283
Grade ^d
Intercept	0.4449	0.4037	1.2146	0.2704	--
HBV	0.8776	0.3814	5.2947	0.0214	2.405
p53 mutation	0.8058	0.3677	4.8033	0.0284	2.239
AFP	0.8056	0.3808	4.4754	0.0344	2.238
β-catenin mutation	-1.4923	0.5578	7.1569	0.0075	0.225
Survival time
ETR	3.3735	0.5685	35.2186	< 0.0001	29.181
Grade	0.4158	0.1448	8.2453	0.0041	1.516
Size	0.0698	0.0247	7.9621	0.0048	1.072

^aLogistic regression model: n = 149, percentage of concordant pairs = 86.5%, percentage of discordant pairs = 13.3%, adjusted generalized R² = 0.3755, Hosmer and Lemeshow goodness-of-fit test P = 0.4583 (degrees of freedom = 8).
^bLogistic regression model: n = 120, percentage of concordant pairs = 84.3%, percentage of discordant pairs = 14.4%, adjusted generalized R² = 0.3507, Hosmer and Lemeshow goodness-of-fit test P = 0.3603 (degrees of freedom = 8).
^cLogistic regression model: n = 125, percentage of concordant pairs = 90.9%, percentage of discordant pairs = 8.9%, adjusted generalized R² = 0.4647, Hosmer and Lemeshow goodness-of-fit test P = 0.7933 (degrees of freedom = 8).
^dLogistic regression model: n = 123, percentage of concordant pairs = 65.8%, percentage of discordant pairs = 21.6%, adjusted generalized R² = 0.2291, Hosmer and Lemeshow goodness-of-fit test P = not applicable.
*↑, mRNA overexpression

ISSN: 1471-2407