From: Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC
Feature | Aurora B overexpression | |||
---|---|---|---|---|
Total | n (%) | OR (95% CI)* | P value | |
Age | ||||
> 55 | 88 | 49 (56) | 1.0 | |
≤55 | 72 | 49 (68) | 1.7 (0.89-3.25) | 0.11 |
Gender | ||||
Female | 38 | 23 (61) | 1.0 | |
Male | 122 | 75 (61) | 1.04 (0.49-2.19) | 0.916 |
HBsAg | ||||
Negative | 53 | 27 (51) | 1.0 | |
Positive | 107 | 71 (66) | 1.9 (0.97-3.72) | 0.06 |
Anti-HCV | ||||
Negative | 100 | 68 (68) | 1.0 | |
Positive | 53 | 30 (57) | 0.8 (0.41-1.57) | 0.517 |
AFP | ||||
< 200 | 80 | 33 (41) | 1.0 | |
≥200 | 80 | 65 (81) | 6.17 (3.01-12.63) | < 0.0001 |
Child-Pugh | ||||
A | 147 | 93 (63) | 1.0 | |
B | 11 | 5 (45) | 0.48 (0.14-1.66) | 0.24 |
Cirrhosis | ||||
No | 99 | 66 (67) | 1.0 | |
Yes | 61 | 32 (52) | 0.55 (0.29-1.06) | 0.073 |
Size (cm) | ||||
≤5 | 72 | 37 (51) | 1.0 | |
> 5 | 88 | 61 (69) | 2.14 (1.12-4.08) | 0.021 |
Grade | ||||
I | 31 | 10 (32) | 1.0 | |
II | 74 | 48 (65) | 3.88 (1.59-9.46) | |
III-IV | 55 | 40 (73) | 5.6 (2.15-14.61) | 0.0007 |
Stage | ||||
I-II | 66 | 21 (32) | 1.0 | |
IIIA-IV | 94 | 77 (82) | 9.71 (4.64-20.3) | < 0.0001 |
ETR† | ||||
No | 76 | 28 (37) | 1.0 | |
Yes | 73 | 61 (84) | 8.71 (4.02-18.91) | < 0.0001 |
5-year survival | ||||
Yes | 56 | 22 (39) | 1.0 | |
No | 104 | 76 (73) | 4.19 (2.11-8.36) | < 0.0001 |
Aurora A overexpression | ||||
No | 60 | 26 (43) | 1.0 | |
Yes | 100 | 72 (72) | 3.36 (1.72-6.58) | 0.0003 |
p53 mutation | ||||
No | 68 | 34 (50) | 1.0 | |
Yes | 66 | 50 (76) | 3.13 (1.5-6.53) | 0.002 |
β-catenin mutation | ||||
No | 128 | 85 (66) | 1.0 | |
Yes | 22 | 7 (32) | 0.24 (0.09-0.62) | 0.002 |