Table 1 Correlation of Aurora B mRNA expression with clinicopathologic and molecular features in 160 patients with primary unifocal HCC by univariate logistic regression analyses

Age

   > 55

1.0

   ≤55

1.7 (0.89-3.25)

0.11

Gender

   Female

1.0

   Male

1.04 (0.49-2.19)

0.916

HBsAg

   Negative

1.0

   Positive

1.9 (0.97-3.72)

0.06

Anti-HCV

   Negative

1.0

   Positive

0.8 (0.41-1.57)

0.517

AFP

   < 200

1.0

   ≥200

6.17 (3.01-12.63)

< 0.0001

Child-Pugh

   A

1.0

   B

0.48 (0.14-1.66)

0.24

Cirrhosis

   No

1.0

   Yes

0.55 (0.29-1.06)

0.073

Size (cm)

   ≤5

1.0

   > 5

2.14 (1.12-4.08)

0.021

Grade

   I

1.0

   II

3.88 (1.59-9.46)

   III-IV

5.6 (2.15-14.61)

0.0007

Stage

   I-II

1.0

   IIIA-IV

9.71 (4.64-20.3)

< 0.0001

ETR†

   No

1.0

   Yes

8.71 (4.02-18.91)

< 0.0001

5-year survival

   Yes

1.0

   No

4.19 (2.11-8.36)

< 0.0001

Aurora A overexpression

   No

1.0

   Yes

3.36 (1.72-6.58)

0.0003

p53 mutation

   No

1.0

   Yes

3.13 (1.5-6.53)

0.002

β-catenin mutation

   No

1.0

   Yes

0.24 (0.09-0.62)

0.002