Table 2 Comparison between IHC or FISH results and histopathological parameters
From: Molecular alterations in key-regulator genes among patients with T4 breast carcinoma
Characteristics | FISH analysis | IHC analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | CyclinD1 | h-prune | p53 | pERK1-2 | survivin | |||||
| Â | positive cases | % | positive cases | % | positive cases | % | positive cases | % | positive cases | % |
Total patients (N = 53) | 12 | 23 | 8 | 15 | 13 | 25 | 5 | 9 | 21 | 40 |
Estrogen receptor (ER) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   negative (N = 20) | 2 | 10 | 1 | 5 | 4 | 20 | 2 | 10 | 9 | 45 |
   positive (N = 24) | 7 | 29 | 5 | 11 | 5 | 21 | 2 | 8 | 7 | 29 |
Progesterone receptor (PR) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   negative (N = 28) | 5 | 18 | 2 | 7 | 5 | 18 | 2 | 7 | 13 | 46 |
   positive (N = 16) | 4 | 25 | 4 | 25 | 4 | 25 | 2 | 12 | 3 | 19 |
Ki67 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   negative (N = 26) | 4 | 15 | 3 | 12 | 4 | 15 | 4 | 15 | 11 | 42 |
   positive (N = 16) | 4 | 25 | 2 | 12 | 5 | 31 | 0 | 0 | 5 | 31 |
HER2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   0-1 (N = 16) | 5 | 31 | 3 | 19 | 2 | 12 | 2 | 12 | 9 | 56 |
   2-3 (N = 37) | 7 | 19 | 5 | 14 | 11 | 30 | 3 | 8 | 12 | 32 |