Genes in overlapping recurrent CNAs of human and mouse breast tumor determined by cross species KC-SMART analyses. Overview of genes in regions found by cross species KC-SMART analysis (Figure 5): listed are genes that map to significantly recurrent regions of gain and loss that overlap between (a) human BRCA1-mutated breast tumors and mouse Brca1
Δ/Δmammary tumors, (b) human BRCA2-mutated breast tumors and mouse Brca2
Δ/Δmammary tumors, (c) human control breast tumors and mouse p53
Δ/Δmammary tumors. The syntenic genomic regions on the human and the mouse genome are listed as well as the amount of mouse genes (M) and human genes (H) mapping within one region of overlap and the amount of unique orthologies for each pair of mouse and human genes (pair). The strand inversion between the two species (when more than one gene maps within the region): 1: no strand inversion, -1: strand inversion. Cancer related genes that map to the regions according to the Atlas of Genetics and Cytogenetics in Oncology and Haematology [44, 45], and the Cancer Gene Census [46, 47] are listed: annotated cancer genes and genes from the Cancer Gene Census are shown in bold type, putative cancer related genes are shown in normal type. Cancer related genes that map closest to the human KSE peak are shown in blue, genes that map closest to the mouse KSE peak are shown in red, and genes that map to the mouse AND human KSE peaks are shown in green. Overlapping regions with only one orthologue are not shown, for a complete list, including genes removed and added see Additional file 6.