Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model

Table 4 Risk stratification based on the 3 independent prognostic factors found in multivariate analysis (number of metastatic sites, time from diagnosis/surgery and PS) and the MSKCC criteria (LDH, Hb, Ca, PS, time from diagnosis/surgery)

Stratification according to the risk factors identified in the current series
Risk factors	Pts	Events	Censored (%)	Mean OS (95% CI)	Median OS (95% CI)
0	15	1	14 (93.3)	25.2 (22.5-27.8)	NR
1	50	17	33 (66.0)	21.8 (18.2-25.3)	NR
2	36	24	12 (33.3)	12.1 (9.7-14.4)	10.8 (9.5-12.2)
3	6	6	0 (0.0)	5.3 (1.4-9.1)	2.9 (0.9-4.9)
Total	107	48	59 (55.1)	18.7 (16.2-21.2)	17.1 (13.9-20.3)
Pairwise Comparison
*No of risk factors*	0		1		2		3
	Chi-Square	p	Chi-Square	p	Chi-Square	p	Chi-Square	p
0			3.680	.055	12.018	.001	22.564	.000
1	3.680	.055			9.368	.002	25.144	.000
2	12.018	.001	9.368	.002			7.969	.005
3	22.564	.000	25.144	.000	7.969	.005
Stratification in 2 prognostic groups
Risk factors	Pts(%)	Events	Censored (%)	Mean OS (95% CI)	Median OS (95% CI)
0 or 1	65	18	47 (72.3)	23.5 (20.4-26.5)	NR
2 or 3	43	30	13 (30.2)	11.3 (9.1-13.4)	10.8 (8.3-13.3)
Total	108	48	60 (55.6)	18.8 (16.3-21.3)	17.1 (13.9-20.3)
Stratification according to the MSKCC model
Risk factors	Pts	Events	Censored (%)	Mean OS (95% CI)	Median OS (95% CI)
0 (favorable)	15	1	14 (93.3)	29.9 (26.7-33.0)	NR
1,2 (intermediate)	56	24	32 (57.1)	19.1 (15.8-22.3)	17.4
3,4,5 (poor)	25	18	7 (28.0)	10.4 (7.9-12.8)	11.1 (3.9-18.4)
Total	96	43	53 (55.2)	18.9 (16.3-21.6)	15.1 (12.1-18.1)
Pairwise Comparisons
*No of risk factors*	0		1,2		3,4,5
	Chi-Square	Sig.	Chi-Square	Sig.	Chi-Square	Sig.
0 (favorable)			5.953	.015	16.052	.000
1,2 (intermediate)	5.953	.015			7.081	.008
3,4,5 (poor)	16.052	.000	7.081	.008

ISSN: 1471-2407