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Table 4 Risk stratification based on the 3 independent prognostic factors found in multivariate analysis (number of metastatic sites, time from diagnosis/surgery and PS) and the MSKCC criteria (LDH, Hb, Ca, PS, time from diagnosis/surgery)

From: Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model

Stratification according to the risk factors identified in the current series
Risk factors Pts Events Censored (%) Mean OS (95% CI) Median OS (95% CI)    
0 15 1 14 (93.3) 25.2 (22.5-27.8) NR    
1 50 17 33 (66.0) 21.8 (18.2-25.3) NR    
2 36 24 12 (33.3) 12.1 (9.7-14.4) 10.8 (9.5-12.2)    
3 6 6 0 (0.0) 5.3 (1.4-9.1) 2.9 (0.9-4.9)    
Total 107 48 59 (55.1) 18.7 (16.2-21.2) 17.1 (13.9-20.3)    
Pairwise Comparison
No of risk factors 0 1 2 3
  Chi-Square p Chi-Square p Chi-Square p Chi-Square p
0    3.680 .055 12.018 .001 22.564 .000
1 3.680 .055    9.368 .002 25.144 .000
2 12.018 .001 9.368 .002    7.969 .005
3 22.564 .000 25.144 .000 7.969 .005   
Stratification in 2 prognostic groups
Risk factors Pts(%) Events Censored (%) Mean OS (95% CI) Median OS (95% CI)    
0 or 1 65 18 47 (72.3) 23.5 (20.4-26.5) NR    
2 or 3 43 30 13 (30.2) 11.3 (9.1-13.4) 10.8 (8.3-13.3)    
Total 108 48 60 (55.6) 18.8 (16.3-21.3) 17.1 (13.9-20.3)    
Stratification according to the MSKCC model
Risk factors Pts Events Censored (%) Mean OS (95% CI) Median OS (95% CI)    
0 (favorable) 15 1 14 (93.3) 29.9 (26.7-33.0) NR    
1,2 (intermediate) 56 24 32 (57.1) 19.1 (15.8-22.3) 17.4    
3,4,5 (poor) 25 18 7 (28.0) 10.4 (7.9-12.8) 11.1 (3.9-18.4)    
Total 96 43 53 (55.2) 18.9 (16.3-21.6) 15.1 (12.1-18.1)    
Pairwise Comparisons
No of risk factors 0 1,2 3,4,5   
  Chi-Square Sig. Chi-Square Sig. Chi-Square Sig.   
0 (favorable)    5.953 .015 16.052 .000   
1,2 (intermediate) 5.953 .015    7.081 .008   
3,4,5 (poor) 16.052 .000 7.081 .008     
  1. NR: not reached