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Figure 5 | BMC Cancer

Figure 5

From: Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

Figure 5

Leptin regulates inflammatory cytokines and MMPs production in HepG2 cells. (a, b) Effect of leptin treatment (200 ng/ml) at different times (24, 48, 72 h) on IL-6 and TGF-b1 production. Columns, mean of three independent experiments done in triplicate; bars, SD, *, p < 0.001 compared to untreated cells, (c) Effect of leptin treatment (50, 200 ng/ml for 48 h and 100 ng/ml for 2 months) and leptin siRNA on MMP-1, MMP-9 and MMP-13 protein levels.

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