Figure 5From: Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase Leptin regulates inflammatory cytokines and MMPs production in HepG2 cells. (a, b) Effect of leptin treatment (200 ng/ml) at different times (24, 48, 72 h) on IL-6 and TGF-b1 production. Columns, mean of three independent experiments done in triplicate; bars, SD, *, p < 0.001 compared to untreated cells, (c) Effect of leptin treatment (50, 200 ng/ml for 48 h and 100 ng/ml for 2 months) and leptin siRNA on MMP-1, MMP-9 and MMP-13 protein levels.Back to article page