Suppression of cell migration and metastasis in SCCHN cells following inhibition of the NF-κB signaling pathway. (a) Treatment with either PDTC or BAY 11-7085 significantly decreased tumor cell invasion. TNFα stimulation further down-regulated cell invasion. (b) Decreased lung metastasis of Tb cells in nude mice. The weight of the lung was measured. The asterisk (*) indicates p < 0.01. (c) Decreased lymph node metastasis of TL cells in nude mice. The popliteal fossa lymph nodes were excised. (c1)Of 10 mice in each group, metastases were detected in eight lymph nodes in the control group, two in the PDTC group and one in the BAY 11-7085 group (c2). The popliteal fossa lymph nodes sections were observed using microscopy at 5× magnification (c3).