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Table 4 Risk ratios for toxicity results

From: Systematic Review of topotecan (Hycamtin) in relapsed small cell lung cancer

 

IV topotecan vs CAV1

IV vs Oral topotecan2

Oral topotecan vs CAV3

Grade 4 neutropenia

0.98 (0.82 to 1.17)

1.47 (1.22 to 1.78)

0.67 (0.51 to 0.87)

Grade 4 thrombocytopenia

5.83 (2.35, 14.42)

0.70 (0.49 to 1.01)

8.41 (3.17 to 22.35)

Grade 4 anaemia

1.46 (0.25 to 8.54)

0.60 (0.22 to 1.65)

2.46 (0.33 to 18.53)

  1. 1- Direct comparison (Von Pawel 1999); 2- Direct comparison (Von Pawel 2001 & Eckardt 2007); 3- Indirect comparison (Von Pawel 1999/Von Pawel 2001 & Eckardt 2007).
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