Factor | OR a (95% CI) | |||||
---|---|---|---|---|---|---|
Cases with TSGb promoter hypermethylation | Cases without TSG promoter hypermethylation | |||||
p16 | DAPK | RARβ | p16 | DAPK | RARβ | |
Smoking habit (yes/no) | 4.56** | 3.83** | 3.11** | 1.34 | 1.23 | 1.45 |
(2.17-9.58) | (1.99-7.38) | (1.67-5.78) | (0.76-2.37) | (0.67-2.26) | (0.77-2.71) | |
Pack years | ||||||
<20 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
(reference) | (reference) | (reference) | (reference) | (reference) | (reference) | |
20-29 | 4.62** | 6.72** | 3.27* | 2.60 | 1.23 | 3.27* |
(1.63-13.13) | (2.63-17.18) | (1.23-8.69) | (0.99-6.80) | (0.37-4.12) | (1.19-9.01) | |
30-39 | 5.08** | 6.82** | 4.27** | 1.75* | 1.58 | 2.70* |
(2.04-12.69) | (2.2.94-15.81) | (1.88-9.70) | (1.19-6.36) | (0.59-4.20) | (1.06-6.89) | |
≥40 | 14.29** | 13.50** | 9.50** | 4.17** | 4.01** | 5.34** |
(6.55-31.18) | (6.31-28.89) | (4.62-19.53) | (1.96-8.88) | (1.85-8.68) | (2.40-11.88) | |
x 2test for trend | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 |
CYP1A1 ((Aa+aa)/AA) c | 0.97 | 1.14 | 1.06 | 1.07 | 0.88 | 0.94 |
(0.55-1.81) | (0.67-1.92) | (0.62-1.80) | (0.61-1.86) | (0.48-1.59) | (0.51-1.71) | |
GSTM1 (null/power) d | 1.45 | 1.73* | 1.98** | 1.67 | 1.33 | 1.10 |
(0.82-2.56) | (1.01-2.99) | (1.15-3.44) | (0.96-2.94) | (0.73-2.43) | (0.60-2.00) |