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Table 1 Clinical features of "Twin 1" and "Twin 2".

From: Monozygotic twins with Neurofibromatosis type 1, concordant phenotype and synchronous development of MPNST and metastasis

Age at diagnosis FEATURE TWIN 1 TWIN 2
At birth CLS + +
  Macrocephaly + +
  Pectus carinatum + -
  Scoliosis + -
  Tibial pseudoarthrosis + -
Childhood Mild psychomotor delay + +
  Developmental dysphasia + +
  Hyperkinesia/attention disorder + +
  Hypotonia - +
  Strabismus - +
  Dental development delay + -
  Right valgus foot + +
  Bilateral flat feet + +
  Normal cranial CT + +
  Normal ophthalmologic examination + +
14 Y/O Radial intraneural neurofibroma + -
20 Y/O Plexiform neurofibroma of the left sciatic nerve + +
(bilateral)
  Multiple neurofibromas surrounding femoropopliteous vessels + -
22 - 24 Y/O MPNST of the left sciatic nerve + (22 Y/O) + (24 Y/O)
24-27 Y/O MPNST recurrences + -
  Osteoporosis - +
  Thymus hyperplasia - +
  Bilateral gynecomastia - +
  Left lung focal pleural thickening + +
  Pleural neurofibroma + (multiple) + (one)
  Hepatic hypodense lesion + +
  Paraspinal plexiform neurofibroma - +
  Psoas plexiform neurofibroma + -
  Multiple retroperitoneal neurofibromas + +
27 Y/O Pulmonary MPNST metastasis + (right lung) + (left lung)