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Table 1 Relationship between EGFR mutation, EGFR copy number and clinicopathological characteristics of lung adenocarcinoma

From: Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas

  IHC   Mutation   FISH  
  + - P value + - P value + - P value
Gender          
   Male 41 21 0.595 34 28 0.042 27 35 0.753
   Female 50 21   51 20   29 42  
Age          
   >60 50 23 0.984 51 22 0.115 30 43 0.795
   <60 41 19   34 26   26 34  
Smoking status          
   Positive 61 25 0.400 62 24 0.008 36 20 0.938
   Negative 30 17   23 24   50 27  
Lymph node metastasis          
   Positive 59 28 0.836 58 29 0.363 33 54 0.180
   Negative 32 14   27 19   23 23  
Stage          
   I 47 22 0.937 45 24 0.744 22 47 0.021
   II 15 2   12 5   11 6  
   III 21 12   19 14   14 19  
   IV 8 6   9 5   8 6  
  1. After Bonferroni correction, P < 0.01 was considered as significant, only the association between EGFR mutation and smoking status was statistically significant.