Figure 1

Effect of 5-FU and CQ on the proliferative activity of HT-29 cells. (A) The proliferative activity of 5-FU-treated HT-29 cells for 24, 48, 72 hours assessed by the MTS assay. The y-axis represents the proliferation rate, calculated as the ratio to control untreated cells. The 5-FU-induced inhibitory effect of HT-29 cells was time and dose-dependently increased. (B) The proliferative activity of CQ-treated HT-29 cells for 12 and 24 hours assessed by the MTS assay. The y-axis represents the proliferation rate, calculated as the ratio to control untreated cells. CQ treatment at 1000 μM for 12 h or 100 μM and higher doses for 24 h resulted in significant inhibition of the proliferative activity of HT-29 cells, but not at lower doses. Values were given as mean.