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Table 4 Prognostic Value of Clinicopathological Factors and SNCG on DFS and OS of 97 Patients with Normal CEA Level

From: Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen

Characteristics DFS OS
  HR (95% CI) P value HR (95% CI) P value
Univariate analysis
   TNM stage (III/IV vs. I/II) 5.703 (2.670-12.182) <0.0001 5.298 (2.483-11.302) <0.0001
   Depth of invasion(pT3 vs. pT1, T2) 3.125 (1.030-9.478) 0.044 3.018 (0.997-9.132) 0.051
   Differentiation (PD vs. WD, MD) 2.167 (1.089-4.312) 0.028 2.191 (1.107-4.338) 0.024
   LN metastasis(Positive vs. Negative) 5.262 (2.466-11.224) <0.0001 4.917 (2.307-10.480) <0.0001
   Intravascular embolus(Positive vs. Negative) 2.503 (1.214-5.161) 0.013 2.638 (1.279-5.418) 0.009
   Tumor size (>4 cm vs. ≤4) 2.876 (1.237-6.683) 0.014 2.886 (1.242-6.705) 0.014
   SNCG (Positive vs. Negative) 2.904 (1.428-5.905) 0.003 2.968 (1.458-6.044) 0.003
Multivariate analysis
   Differentiation (PD vs. WD, MD) 2.372 (1.128-4.990) 0.023 2.035 (1.042-3.977) 0.038
   Tumor size (>4 cm vs. ≤4) 2.734 (1.169-6.394) 0.020 2.545 (1.089-5.951) 0.031
   SNCG (Positive vs. Negative) 3.491 (1.656-7.359) 0.001 3.132 (1.506-6.511) 0.002
  1. WD, well-differentiated; MD, moderately differentiated; PD, poorly differentiated; LN, lymph node; HR, hazard ratio; CI, confidence interval.