Table 4 Prognostic Value of Clinicopathological Factors and SNCG on DFS and OS of 97 Patients with Normal CEA Level

Univariate analysis

   TNM stage (III/IV vs. I/II)

5.703 (2.670-12.182)

<0.0001

5.298 (2.483-11.302)

<0.0001

   Depth of invasion(pT3 vs. pT1, T2)

3.125 (1.030-9.478)

0.044

3.018 (0.997-9.132)

0.051

   Differentiation (PD vs. WD, MD)

2.167 (1.089-4.312)

0.028

2.191 (1.107-4.338)

0.024

   LN metastasis(Positive vs. Negative)

5.262 (2.466-11.224)

<0.0001

4.917 (2.307-10.480)

<0.0001

   Intravascular embolus(Positive vs. Negative)

2.503 (1.214-5.161)

0.013

2.638 (1.279-5.418)

0.009

   Tumor size (>4 cm vs. ≤4)

2.876 (1.237-6.683)

0.014

2.886 (1.242-6.705)

0.014

   SNCG (Positive vs. Negative)

2.904 (1.428-5.905)

0.003

2.968 (1.458-6.044)

0.003

Multivariate analysis

   Differentiation (PD vs. WD, MD)

2.372 (1.128-4.990)

0.023

2.035 (1.042-3.977)

0.038

   Tumor size (>4 cm vs. ≤4)

2.734 (1.169-6.394)

0.020

2.545 (1.089-5.951)

0.031

   SNCG (Positive vs. Negative)

3.491 (1.656-7.359)

0.001

3.132 (1.506-6.511)

0.002