Characteristics | DFS | OS | ||
---|---|---|---|---|
 | HR (95% CI) | P value | HR (95% CI) | P value |
Univariate analysis | ||||
   TNM stage (III/IV vs. I/II) | 4.745 (2.873-7.837) | <0.0001 | 4.667 (2.827-7.704) | <0.0001 |
   Depth of invasion(pT3 vs. pT1, T2) | 3.539 (1.489-8.410) | 0.004 | 3.507 (1.476-8.331) | 0.004 |
   Differentiation (PD vs. WD, MD) | 1.733 (1.130-2.658) | 0.012 | 1.741 (1.144-2.649) | 0.010 |
   LN metastasis(Positive vs. Negative) | 3.701 (2.303-5.946) | <0.0001 | 3.593 (2.237-5.771) | <0.0001 |
   Intravascular embolus(Positive vs. Negative) | 1.933 (1.202-3.106) | 0.006 | 2.021 (1.257-3.248) | 0.004 |
   CEA (Positive vs. Negative) | 2.761 (1.739-4.383) | <0.0001 | 2.776 (1.750-4.405) | <0.0001 |
   SNCG (Positive vs. Negative) | 2.146 (1.367-3.368) | 0.001 | 2.121 (1.351-3.331) | 0.001 |
   SNCG/CEA (either positive vs. both negative) | 3.756 (2.097-6.729) | <0.0001 | 3.811 (2.127-6.830) | <0.0001 |
Multivariate analysis | ||||
   TNM stage (III/IV vs. I/II) | 3.251 (1.209-8.748) | 0.020 | 3.904 (1.447-10.536) | 0.007 |
   Depth of invasion (pT3 vs. pT1, T2) | 3.701 (1.449-9.450) | 0.006 | 3.819 (1.488-9.805) | 0.005 |
   Differentiation (PD vs. WD, MD) | 2.116 (1.309-3.422) | 0.002 | 2.075 (1.313-3.299) | 0.002 |
   CEA (Positive vs. Negative) | 2.440 (1.493-3.987) | <0.0001 | 2.639 (1.615-4.315) | <0.0001 |
   SNCG (Positive vs. Negative) | 2.213 (1.391-3.520) | 0.001 | 2.141 (1.349-3.401) | 0.001 |
   SNCG/CEA (either positive vs. both negative) | 3.517 (1.936-6.389) | <0.0001 | 3.645 (2.005-6.629) | <0.0001 |