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Table 3 Prognostic Value of Clinicopathological Factors, CEA, SNCG, and Combined CEA and SNCG on DFS and OS of 170 Patients with Colon Adenocarcinoma

From: Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen

Characteristics DFS OS
  HR (95% CI) P value HR (95% CI) P value
Univariate analysis
   TNM stage (III/IV vs. I/II) 4.745 (2.873-7.837) <0.0001 4.667 (2.827-7.704) <0.0001
   Depth of invasion(pT3 vs. pT1, T2) 3.539 (1.489-8.410) 0.004 3.507 (1.476-8.331) 0.004
   Differentiation (PD vs. WD, MD) 1.733 (1.130-2.658) 0.012 1.741 (1.144-2.649) 0.010
   LN metastasis(Positive vs. Negative) 3.701 (2.303-5.946) <0.0001 3.593 (2.237-5.771) <0.0001
   Intravascular embolus(Positive vs. Negative) 1.933 (1.202-3.106) 0.006 2.021 (1.257-3.248) 0.004
   CEA (Positive vs. Negative) 2.761 (1.739-4.383) <0.0001 2.776 (1.750-4.405) <0.0001
   SNCG (Positive vs. Negative) 2.146 (1.367-3.368) 0.001 2.121 (1.351-3.331) 0.001
   SNCG/CEA (either positive vs. both negative) 3.756 (2.097-6.729) <0.0001 3.811 (2.127-6.830) <0.0001
Multivariate analysis
   TNM stage (III/IV vs. I/II) 3.251 (1.209-8.748) 0.020 3.904 (1.447-10.536) 0.007
   Depth of invasion (pT3 vs. pT1, T2) 3.701 (1.449-9.450) 0.006 3.819 (1.488-9.805) 0.005
   Differentiation (PD vs. WD, MD) 2.116 (1.309-3.422) 0.002 2.075 (1.313-3.299) 0.002
   CEA (Positive vs. Negative) 2.440 (1.493-3.987) <0.0001 2.639 (1.615-4.315) <0.0001
   SNCG (Positive vs. Negative) 2.213 (1.391-3.520) 0.001 2.141 (1.349-3.401) 0.001
   SNCG/CEA (either positive vs. both negative) 3.517 (1.936-6.389) <0.0001 3.645 (2.005-6.629) <0.0001
  1. WD, well-differentiated; MD, moderately differentiated; PD, poorly differentiated; LN, lymph node; HR, hazard ratio; CI, confidence interval.