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Table 1 Correlations of SNCG Expression with Clinicopathologic Factors and Their Influences on Postoperative Recurrence

From: Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen

Characteristics No. of cases SNCG expression No. of recurrence (%) HR (95%CI) P value
   SNCG+ (%) P value    
Gender       
   Male 121 38 (31.4) 0.066 28 (23.1) 1 0.205
   Female 108 36 (33.3)   33 (30.6) 1.461 (0.811-2.632)  
Age (yrs)       
   ≤60 89 31 (34.8) 0.516 22 (24.7) 1 0.601
   >60 140 43 (32.9)   39 (27.9) 1.176 (0.641-2.581)  
Size (cm)       
   ≤4 90 23 (25.6) 0.072 19 (21.1) 1 0.120
   >4 138 51 (37.0)   42 (30.4) 1.635 (0.877-3.047)  
TNM stage       
   I/II 114 32 (28.1) 0.172 14 (12.3) 1 0.000
   III/IV 115 42 (36.5)   47 (40.9) 4.937 (2.522-9.663)  
Depth of invasion       
   pT1 and pT2 39 12 (30.8) 0.821 4 (10.3) 1 0.011
   pT3 190 62 (32.6)   57 (30.0) 3.750 (1.273-11.043)  
Differentiation       
   WD and MD 192 61 (31.8) 0.689 49 (25.5) 1 0.384
   PD 37 13 (35.1)   12 (32.4) 1.401 (0.654-2.998)  
LN metastasis       
   Negative 125 37 (29.6) 0.336 20 (16.0) 1 0.000
   Positive 104 37 (35.6)   41 (39.4) 3.417 (1.840-6.346)  
Intravascular embolus       
   Negative 170 48 (28.2) 0.025 40 (23.5) 1 0.071
   Positive 59 26 (44.1)   21 (35.6) 1.796 (0.947-3.406)  
CEA       
   Negative 97 34 (35.1) 0.658 15 (15.5) 1 0.001
   Positive 73 28 (38.4)   28 (38.4) 3.401 (1.648-7.023)  
   ND 59      
SNCG       
   Negative 155 ---- ---- 34 (22.2) 1 0.020
   Positive 74 ----   27 (36.5) 2.044 (1.114-3.752)  
  1. WD, well-differentiated; MD, moderately differentiated; PD, poorly differentiated; LN, lymph node; HR, hazard ratio; CI, confidence interval; ND, Not Detected.